Advertisement

Virchows Archiv

, Volume 446, Issue 4, pp 463–466 | Cite as

An unusual presentation of helicobacter pylori infection: so-called “Russell body gastritis”

  • Arzu Ensari
  • Berna Savas
  • Aylin Okcu Heper
  • Isinsu Kuzu
  • Ramazan Idilman
Case Report

Abstract

Helicobacter pylori (H. pylori) is a “slow” bacterial pathogen, which induces several gastroduodenal diseases. Varying degrees of inflammation can be present in the gastric mucosa of patients infected with H. pylori. The case presented here is a male patient suffering from dyspepsia and nausea. His upper gastrointestinal endoscopy revealed pan gastritis. Histological examination of multiple gastric biopsies taken from the body and antrum showed a rare morphological expression of H. pylori gastritis characterized by diffuse plasma cell infiltration with extensive Russell body formation. Diffuse infiltration of plasma cells with Russell bodies in gastric mucosa can cause difficulties in differentiation from neoplastic processes. However, immunohistochemically, the infiltrating cells in the gastric mucosa stained negatively with cytokeratins while they expressed both kappa and lambda light chains showing their polyclonal nature. The presence of diffuse plasma cells with Russell bodies in the gastric mucosa may represent a different presentation of H. pylori gastritis. There are only two case reports of similar presentation and both have been called “Russell body gastritis”.

Keywords

Helicobacter pylori Russell body gastritis 

References

  1. 1.
    Bolin TD, Hunt TR, Korman MG, Lambert JR, Lee A, Talley NJ (1995) Helicobacter pylori a gastric neoplasia: evolving concepts. Med J Aust 163:235–255Google Scholar
  2. 2.
    Chan AO, Chu KM, Yuen ST, Leung SY, Lam SK, Wong J (2001) Synchronous gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma in Helicobacter pylori infection; comparing reported cases between the east and west. Am J Gastroenterol 96:1922–1924Google Scholar
  3. 3.
    Erbersdobler A, Petri S, Lock G (2004) Russell body gastritis. An usual, tumor-like lesion of the gastric mucosa. Arch Pathol Lab Med 128:915–917Google Scholar
  4. 4.
    Ernst PB, Crowe SE, Reyes VE (1997) How does Helicobacter pylori cause mucosal damage? The inflammatory response. Gastroenterology 113:S35–S42Google Scholar
  5. 5.
    Ernst PB, Gold BD (2000) The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol 54:615–640Google Scholar
  6. 6.
    Genta RM (1997) Role of Helicobacter pylori infection in cancer. Helicobacter pylori, inflammation, mucosal damage, and apoptosis: pathogenesis and definition of gastric atrophy. Gastroenterology 113:S51–S55Google Scholar
  7. 7.
    Hsu SM, Hsu PL, McMillan PN, Fanger H (1982) Russell bodies: a light and electron microscopic immunoperoxidase study. Am J Clin Pathol 77:26–31Google Scholar
  8. 8.
    Isaacson PG (1990) Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology 16:617–619Google Scholar
  9. 9.
    Kokoska ER, Kauffman GL Jr (2001) Helicobacter pylori and the gastroduodenal mucosa. Surgery 130:13–16Google Scholar
  10. 10.
    Russell W (1890) An address on a characteristic organism of cancer. BMJ 2:1356–1360Google Scholar
  11. 11.
    Tazawa K, Tsutsumi Y (1998) Localized accumulation of Russell body-containing plasma cells in gastric mucosa with helicobacter pylori infection: “Russell body gastritis”. Pathol Int 48:242–244Google Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Arzu Ensari
    • 1
  • Berna Savas
    • 1
  • Aylin Okcu Heper
    • 1
  • Isinsu Kuzu
    • 1
  • Ramazan Idilman
    • 2
  1. 1.Department of Pathology, Medical SchoolAnkara University AnkaraTurkey
  2. 2.Department of Gastroenterology, Medical SchoolAnkara University AnkaraTurkey

Personalised recommendations