Virchows Archiv

, Volume 449, Issue 1, pp 78–87 | Cite as

Peripheral T-cell lymphoma with involvement of the expanded mantle zone

  • Ida Münster IkonomouEmail author
  • Anne Tierens
  • Gunhild Troen
  • Hege Vangstein Aamot
  • Sverre Heim
  • Grete F. Lauritzsen
  • Helen Vålerhaugen
  • Jan Delabie
Original Article


Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they represent a separate T-cell lymphoma type remains to be demonstrated by a study of more of such cases.


Lymphoma T-cell Peripheral Bcl-6 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Ida Münster Ikonomou
    • 1
    Email author
  • Anne Tierens
    • 1
  • Gunhild Troen
    • 1
  • Hege Vangstein Aamot
    • 2
  • Sverre Heim
    • 2
  • Grete F. Lauritzsen
    • 3
  • Helen Vålerhaugen
    • 1
  • Jan Delabie
    • 1
  1. 1.Department of Pathology, The Norwegian Radium HospitalUniversity of OsloOsloNorway
  2. 2.Department of Cancer Genetics, The Norwegian Radium HospitalUniversity of OsloOsloNorway
  3. 3.Department of Oncology, The Norwegian Radium HospitalUniversity of OsloOsloNorway

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