Virchows Archiv

, Volume 447, Issue 5, pp 787–793

Molecular pathology of well-differentiated thyroid carcinomas

  • Manuel Sobrinho-Simões
  • Ana Preto
  • Ana Sofia Rocha
  • Patrícia Castro
  • Valdemar Máximo
  • Elsa Fonseca
  • Paula Soares
Review Article

DOI: 10.1007/s00428-005-0065-5

Cite this article as:
Sobrinho-Simões, M., Preto, A., Rocha, A.S. et al. Virchows Arch (2005) 447: 787. doi:10.1007/s00428-005-0065-5

Abstract

The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: “Follicular carcinoma”, “Papillary carcinoma”, “Follicular variant of papillary carcinoma” and “Hürthle cell tumours”. A particular emphasis is put on the meaning of PAX8–PPARγ rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.

Keywords

Thyroid Follicular carcinoma Papillary carcinoma Follicular variant of papillary carcinoma Hürthle cell tumours RET/PTC rearrangements BRAF mutations RAS mutations 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Manuel Sobrinho-Simões
    • 1
    • 2
    • 3
  • Ana Preto
    • 1
  • Ana Sofia Rocha
    • 1
  • Patrícia Castro
    • 1
    • 2
  • Valdemar Máximo
    • 1
  • Elsa Fonseca
    • 1
    • 2
    • 3
  • Paula Soares
    • 1
    • 2
  1. 1.Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)PortoPortugal
  2. 2.Department of PathologyMedical Faculty of the University of PortoPortoPortugal
  3. 3.Department of PathologyUniversity Hospital of S. JoãoPortoPortugal

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