Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues
- 360 Downloads
Perineurioma represents a recently described and relatively rare neoplasm in the spectrum of benign peripheral nerve sheath tumours composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen (EMA). In addition to intraneural, extraneural and sclerosing perineurioma, rare variants of perineurioma may occur, and their knowledge is important in the differential diagnosis of mesenchymal tumours of different lines of differentiation and clinically more aggressive neoplasms. We present a case of deep-seated reticular perineurioma arising on the upper arm of a 34-year-old female and a case of a dermal plexiform perineurioma arising on the lower lip of a 60-year-old female. The diagnosis was confirmed in both cases immunohistochemically; neoplastic cells stained positively for EMA and for the newly described perineurial markers, claudin-1 and glut-1. The morphological spectrum and the differential diagnosis of perineurial neoplasms of skin and soft tissues are discussed.
KeywordsNerve sheath neoplasms Perineurioma Epithelial membrane antigen Claudin-1 Human erythrocyte glucose transporter (glut-1)
The authors are grateful to Dr. Outrata, Stuttgart, Germany, for kindly providing case material and clinical follow-up for case 1.
- 23.Michal M, Kazakov DV, Belousova I, Bisceglia M, Zamecnik M, Mukensnabl P (2004) A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma–perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch 445:347–353CrossRefPubMedGoogle Scholar
- 26.Scheithauer BW, Giannini C, Woodruff JM (2000) Perineurioma. In: Kleihues P, Cavenee WK (eds) WHO-classification. Tumours of the nervous system. IARC Press, LyonGoogle Scholar
- 34.Zelger BG, Weinlich G, Zelger B (2000) Perineuroma. A frequently unrecognized entity with emphasis on a plexiform variant. Adv Clin Pathol 4:25–33Google Scholar