Virchows Archiv

, Volume 447, Issue 6, pp 978–983 | Cite as

Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature

  • Sophie Ferlicot
  • Yves Allory
  • Eva Compérat
  • Florence Mege-Lechevalier
  • Stéphanie Dimet
  • Mathilde Sibony
  • Jérome Couturier
  • Annick Vieillefond
Original Article

Abstract

Mucinous tubular and spindle cell carcinomas are low-grade renal epithelial neoplasms, which were first recognized as a specific entity in the World Health Organization 2004 classification. Forty-five documented cases have been reported. We present 15 additional cases that were incidentally discovered in ten women and five men, with a mean age of 53 years. The tumor is characteristically made up of large eosinophilic regular spindle cells separated by a myxoid stroma with intercellular alcian-blue-positive clear droplets. In peripheral areas, elongated tubules and papillae covered by cubic cells are found. Until this entity had been defined, pathologists used to classify these tumors as variants of solid papillary carcinomas with compressed and elongated papillae, metanephric adenomas, and sarcomatoid carcinomas. In the literature, cytogenetic data indicate various chromosomal losses and gains, but no loss of 3p or trisomy 7 and/or trisomy 17. In two cases, we demonstrate chromosomal loss involving chromosomes 1, 4, 6, 11, 8, 13, 14, 15, 18, and 22. In our 15 cases, immunohistochemistry favored a distal tubule origin (EMA+, AE1/AE3+, CK7+, CK19+, E-cadherin+, AMACR+, and CD10). Prognosis was favorable in our cases, while in the literature, two metastatic cases were reported. Further investigations are required to determine the frequency and true prognosis of these tumors, which are easily identifiable morphologically.

Keywords

Spindle cells Mucinous stroma Low grade Tubular renal carcinoma 

Notes

Acknowledgements

We thank Dr. Bergemere-Fouquet (Tours), Dr. Billey Kijner (Villennes-sur-Seine), Dr. Bourdier (Brest), Dr. Bouvier (Lyon), Dr. Chanoz-Poulard (Roanne), Dr. Douchet (Saint-Etienne), Dr. Hibon (Reims), Dr. Jouannelle (Fort de France), Dr. Kaffe (Paris), Dr. Kapfer (Orléans), Dr. Krzisch (Colmar), Prof. Lhuintre (Tours), Dr. Loridon (Paris), Dr. Mirica (Paris), Dr. Tricot (St. Germain-en-Laye), and Dr. Vuong (Bièvres) for kindly providing the cases and the illustrations.

References

  1. 1.
    Eble JN (2003) Mucinous tubular and spindle cell carcinoma and post-neuroblastoma carcinoma: newly recognised entities in the renal cell carcinoma family. Pathology 35:499–504CrossRefPubMedGoogle Scholar
  2. 2.
    Ferlicot S, Lupo A, Lazure T, Bedossa P, Vieillefond A (2005) A novel entity: low grade mucinous tubular renal carcinoma. Histopathology 47:218–219CrossRefPubMedGoogle Scholar
  3. 3.
    He Q, Ohaki Y, Mori O, Asano G, Tuboi N (1998) A case report of renal cell tumor in a 45-year-old female mimicking lower portion nephrogenesis. Pathol Int 48:416–420PubMedCrossRefGoogle Scholar
  4. 4.
    Hes O, Hora M, Perez-Montiel DM, Suster S, Curik R, Sokol L, Ondic O, Mikulastik J, Betlach J, Peychl L, Hrabal P, Kodet R, Straka L, Ferak I, Vrabec V, Michal M (2002) Spindle and cuboidal renal cell carcinoma, a tumor having frequent association with nephrolithiasis: report of 11 cases including a case with hybrid conventional renal cell carcinoma/spindle and cuboidal renal cell carcinoma components. Histopathology 4:549–555CrossRefGoogle Scholar
  5. 5.
    Leroy X, Aubert S, Gosselin B (2002) Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation: a distinct clinicopathologic entity? Human Pathol 33:574–575CrossRefGoogle Scholar
  6. 6.
    Meloni-Ehrig AM (2002) Renal cancer: cytogenetic and molecular genetic aspects. Am J Med Genet 115(3):164–172CrossRefPubMedGoogle Scholar
  7. 7.
    Otani M, Shimizu T, Serizawa H, Ebihara Y, Nagashima Y (2001) Low-grade renal cell carcinoma arising from the lower nephron: a case report with immunohistochemical, histochemical and ultrastructural studies. Pathol Int 51:954–960CrossRefPubMedGoogle Scholar
  8. 8.
    Parwani AV, Husain AN, Epstein JI, Beckwith JB, Argani P (2001) Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation. Human Pathol 32:506–512CrossRefGoogle Scholar
  9. 9.
    Rakozy C, Schmahl GE, Bogner S, Störkel S (2002) Low-grade tubular–mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol 15:1162–1171CrossRefPubMedGoogle Scholar
  10. 10.
    Srigley JR, Eble JN, Grignon DJ, Hartwick RWJ (1999) Unusual renal cell carcinoma (RCC) with prominent spindle cell change possibly related to the loop of Henle. Mod Pathol 12:107AGoogle Scholar
  11. 11.
    Srigley JR (2004) Mucinous tubular and spindle cell carcinoma. WHO classification of tumors In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) Tumors of the genito-urinary and male genital organs. IARC, Washington, DC, USAGoogle Scholar
  12. 12.
    Tretiakova MS, Sahoo S, Takahashi M, Turkyilmaz M, Vogelzang NJ, Lin F, Krausz T, Teh BT, Yang XJ (2004) Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol 28:69–76PubMedCrossRefGoogle Scholar
  13. 13.
    Weber A, Srigley J, Moch H (2003) Mucinous spindle cell carcinoma of the kidney. A molecular analysis. Pathologe 24:453–459CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Sophie Ferlicot
    • 1
  • Yves Allory
    • 2
  • Eva Compérat
    • 3
  • Florence Mege-Lechevalier
    • 4
  • Stéphanie Dimet
    • 1
  • Mathilde Sibony
    • 5
  • Jérome Couturier
    • 6
  • Annick Vieillefond
    • 7
  1. 1.Service d'Anatomie PathologiqueHôpital de BicêtreParisFrance
  2. 2.Service d'Anatomie PathologiqueHôpital Henri MondorCréteilFrance
  3. 3.Service d'Anatomie PathologiqueHôpital La Pitié SalpêtrièreParisFrance
  4. 4.Service d'Anatomie PathologiqueHôpital Edouard HerriotLyonFrance
  5. 5.Service d'Anatomie PathologiqueHôpital TenonParisFrance
  6. 6.Department de Génétique, Section MédicaleInstitut CurieParisFrance
  7. 7.Service d'Anatomie PathologiqueHôpital CochinParisFrance

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