Virchows Archiv

, Volume 447, Issue 4, pp 717–722 | Cite as

Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer

  • Reiko Ito
  • Naohide Oue
  • Kazuhiro Yoshida
  • Kyoko Kunimitsu
  • Hirofumi Nakayama
  • Kei Nakachi
  • Wataru Yasui
Original Article

Abstract

Cadherin-17 (CDH17), also called liver–intestine cadherin, is a structurally unique member of the cadherin superfamily. Our serial analysis of gene expression demonstrated that CDH17 was one of the most up-regulated genes in advanced gastric carcinomas. CDH17 expression is known to be regulated by Cdx2. In the present study, we examined the expression of CDH17 in primary gastric carcinoma tissues by immunohistochemistry, and analyzed the correlation of CDH17 expression with clinicopathological characteristics and patients prognosis. CDH17 expression was detected in 63/94 (67%) of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of CDH17 tended to be associated with intestinal type carcinoma, and carcinomas with CDH17 expression was significantly more frequent in advanced stage cases (80%) than in early stage (53%). The prognosis of patients with positive CDH17 expression was significantly poorer than that of the negative cases (P=0.0314). However, multivariate analysis revealed that CDH17 was not an independent prognostic factor. Six of seven cases that showed positive expression of Cdx2 simultaneously expressed CDH17 protein. These results suggested that the expression of CDH17 was characteristic of the advanced gastric carcinoma that is associated with poor prognosis.

Keywords

CDH17 Gastric carcinoma Prognosis Immunohistochemistry 

Notes

Acknowledgements

This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, and Technology of Japan, and the Ministry of Health, Labor, and Welfare of Japan. The authors thank Masayoshi Takatani and Mutsumi Ueda for their skillful technical assistance.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Reiko Ito
    • 1
  • Naohide Oue
    • 2
  • Kazuhiro Yoshida
    • 3
  • Kyoko Kunimitsu
    • 2
  • Hirofumi Nakayama
    • 2
  • Kei Nakachi
    • 1
  • Wataru Yasui
    • 2
  1. 1.Department of Radiobiology/Molecular EpidemiologyRadiation Effect Research FoundationHiroshimaJapan
  2. 2.Department of Molecular PathologyHiroshima University Graduate School of Biomedical SciencesHiroshimaJapan
  3. 3.Department of Surgical OncologyResearch Institute for Radiation Biology and Medicine, Hiroshima UniversityHiroshimaJapan

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