Undifferentiated (sarcomatous) carcinoma of the liver with osteoclast-like giant cells presenting as tumor thrombus in the inferior vena cava
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Hepatic tumors containing osteoclast-like giant cells (OGC) are very rare, and only few cases have been published since they were first reported by Munoz and co-workers in 1980 . The nature of these tumors and the histogenetic origin of the giant cells have remained obscure for a long time. However, the association of hepatocellular carcinoma with highly pleomorphic tumor areas containing OGC has been recently described , a finding that was also confirmed by other authors. On the other hand, hepatic sarcomatous cholangiocarcinomas are also very uncommon, with only 17 cases published to date , and only one single cholangiocarcinoma with OGC has been reported .
We describe an extraordinary case of a cytokeratin 19-positive undifferentiated carcinoma with OGC and predominantly intravasal tumor growth into the heart, a manifestation of tumor spread resembling leiomyosarcomas of the inferior vena cava.
KeywordsHepatic Tumor Tumor Thrombus Giant Cell Tumor Carcinosarcoma Undifferentiated Carcinoma
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