Virchows Archiv

, Volume 448, Issue 5, pp 659–660 | Cite as

Undifferentiated (sarcomatous) carcinoma of the liver with osteoclast-like giant cells presenting as tumor thrombus in the inferior vena cava

  • Hans-Ulrich Schildhaus
  • Frank DombrowskiEmail author
Letter to the Editor

Dear Editor:

Hepatic tumors containing osteoclast-like giant cells (OGC) are very rare, and only few cases have been published since they were first reported by Munoz and co-workers in 1980 [4]. The nature of these tumors and the histogenetic origin of the giant cells have remained obscure for a long time. However, the association of hepatocellular carcinoma with highly pleomorphic tumor areas containing OGC has been recently described [3], a finding that was also confirmed by other authors. On the other hand, hepatic sarcomatous cholangiocarcinomas are also very uncommon, with only 17 cases published to date [2], and only one single cholangiocarcinoma with OGC has been reported [1].

We describe an extraordinary case of a cytokeratin 19-positive undifferentiated carcinoma with OGC and predominantly intravasal tumor growth into the heart, a manifestation of tumor spread resembling leiomyosarcomas of the inferior vena cava.

The patient, a 77-year-old Caucasian woman suffering from...


Hepatic Tumor Tumor Thrombus Giant Cell Tumor Carcinosarcoma Undifferentiated Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Haratake J, Yamada H, Horie A, Inokuma T (1992) Giant cell tumor-like cholangiocarcinoma associated with systemic cholelithiasis. Cancer 69:2444–2448PubMedCrossRefGoogle Scholar
  2. 2.
    Kaibori M, Kawaguchi Y, Yokoigawa N, Yanagida H, Takai S, Kwon AH, Uemura Y, Kamiyama Y (2003) Intrahepatic sarcomatoid cholangiocarcinoma. J Gastroenterol 38:1097–1101PubMedCrossRefGoogle Scholar
  3. 3.
    Kuwano H, Sonoda T, Hashimoto H, Enjoji M (1984) Hepatocellular carcinoma with osteoclast-like giant cells. Cancer 54:837–842PubMedCrossRefGoogle Scholar
  4. 4.
    Munoz PA, Rao MS, Reddy JK (1980) Osteoclastoma-like giant tumor of the liver. Cancer 46:771–779PubMedCrossRefGoogle Scholar
  5. 5.
    Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH (1998) K-ras oncogen mutations in osteoclast-like giant cell tumors of the pancreas and liver. Genetic evidence to support origin from duct epithelium. Am J Surg Pathol 22:1247–1254PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of PathologyOtto von Guericke UniversityMagdeburgGermany

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