Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation
Sir, mesenchymal tumors of the pancreas are exceedingly rare, accounting for less than 1% of all pancreatic tumors, and most of them have been reported in small series or as single case reports. This group of pancreatic tumors includes leiomyosarcoma, malignant peripheral nerve sheath tumor, malignant fibrous histiocytoma, liposarcoma, rhabdomyosarcoma, hemangiopericytoma, schwannoma and solitary fibrous tumor. In the gut, mesenchymal tumors are more common, and the majority of these are formed by gastrointestinal stromal tumors (GISTs). GISTs are defined as KIT-positive mesenchymal spindle cell or epithelioid neoplasms showing differentiation toward the interstitial cell of Cajal. GISTs occur most commonly in the stomach (60–70%), small intestine (20–25%), colorectum (5%) and esophagus (<5%). They were also occasionally reported in extragastrointestinal sites, such as urinary bladder, gallbladder, omentum and mesentery . We report a case of a GIST of the pancreatic head in a...
KeywordsPancreatic Duct Pancreatic Head Gastrointestinal Stromal Tumor Imatinib Mesylate Malignant Peripheral Nerve Sheath Tumor
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