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Virchows Archiv

, Volume 446, Issue 4, pp 470–472 | Cite as

Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation

  • Ondrej Daum
  • Jiri Klecka
  • Jiri Ferda
  • Vladimir Treska
  • Tomas Vanecek
  • Radek Sima
  • Petr Mukensnabl
  • Michal Michal
Letter to the Editor

Sir, mesenchymal tumors of the pancreas are exceedingly rare, accounting for less than 1% of all pancreatic tumors, and most of them have been reported in small series or as single case reports. This group of pancreatic tumors includes leiomyosarcoma, malignant peripheral nerve sheath tumor, malignant fibrous histiocytoma, liposarcoma, rhabdomyosarcoma, hemangiopericytoma, schwannoma and solitary fibrous tumor. In the gut, mesenchymal tumors are more common, and the majority of these are formed by gastrointestinal stromal tumors (GISTs). GISTs are defined as KIT-positive mesenchymal spindle cell or epithelioid neoplasms showing differentiation toward the interstitial cell of Cajal. GISTs occur most commonly in the stomach (60–70%), small intestine (20–25%), colorectum (5%) and esophagus (<5%). They were also occasionally reported in extragastrointestinal sites, such as urinary bladder, gallbladder, omentum and mesentery [1]. We report a case of a GIST of the pancreatic head in a...

Keywords

Pancreatic Duct Pancreatic Head Gastrointestinal Stromal Tumor Imatinib Mesylate Malignant Peripheral Nerve Sheath Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ondrej Daum
    • 1
  • Jiri Klecka
    • 2
  • Jiri Ferda
    • 3
  • Vladimir Treska
    • 2
  • Tomas Vanecek
    • 4
  • Radek Sima
    • 4
  • Petr Mukensnabl
    • 1
  • Michal Michal
    • 4
  1. 1.Sikl’s Department of PathologyMedical Faculty HospitalPlzen (Pilsen)Czech Republic
  2. 2.Surgical ClinicMedical Faculty HospitalPlzen (Pilsen)Czech Republic
  3. 3.Radiological ClinicMedical Faculty HospitalPlzen (Pilsen)Czech Republic
  4. 4.Sikl’s Department of Pathology, Laborator Spec. DiagnostikyMedical Faculty HospitalPlzen (Pilsen)Czech Republic

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