Virchows Archiv

, Volume 446, Issue 5, pp 537–541

Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

  • Ryoji Kushima
  • Michael Vieth
  • Ken-ichi Mukaisho
  • Rie Sakai
  • Hidetoshi Okabe
  • Takanori Hattori
  • Horst Neuhaus
  • Franz Borchard
  • Manfred Stolte
Case Report


Pyloric gland adenoma is a recently described and very rare entity. The occurrence of adenoma is very unusual in Barrett’s epithelium of the esophagus. We report a case of esophageal polyp showing the features of pyloric gland adenoma, which was surrounded by so-called specialized columnar epithelium. Immunohistochemically, most tumor glands were strongly positive for MUC6, except in the superficial layer. MUC5AC was positive in almost all tumor cells, but MUC2 and CD10 were negative in the tumor. MIB-1-positive proliferating cells were distributed throughout the tumor. Microdissection and comparative genomic hybridization analyses revealed losses on 2p24–25.2, 2q14.1-ter, 5q31.3–32, 6q23–24, 8q23–24.2, 11q22.3–24 and 18q21.1–22. This is the first case of pyloric gland adenoma found to arise in Barrett’s epithelium of the esophagus, showing its unstable and precancerous nature.


Pyloric gland adenoma Barrett’s epithelium Esophagus Mucin CGH 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ryoji Kushima
    • 1
  • Michael Vieth
    • 2
  • Ken-ichi Mukaisho
    • 3
  • Rie Sakai
    • 1
  • Hidetoshi Okabe
    • 1
  • Takanori Hattori
    • 3
  • Horst Neuhaus
    • 4
  • Franz Borchard
    • 5
  • Manfred Stolte
    • 2
  1. 1.Division of Diagnostic PathologyShiga University of Medical ScienceShigaJapan
  2. 2.Institute of PathologyKlinikum BayreuthBayreuthGermany
  3. 3.Department of PathologyShiga University of Medical ScienceShigaJapan
  4. 4.Department of General Internal MedicineEvangelisches Krankenhaus DüsseldorfDüsseldorfGermany
  5. 5.Institute of PathologyKlinikum AschaffenburgAschaffenburgGermany

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