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Regeneration of gastric mucosa during ulcer healing follows pathways that correspond to the ontogenetic course of rat fundic glands

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Abstract

Gastric ulcers in humans are notoriously chronic and recurring lesions. Although the average individual who undergoes no treatments requires many years for healing, most studies on the healing process of the experimentally induced ulcers have mainly focused on the early stages. Natural history of the ulcer healing has not been completely revealed. We have undertaken long-term investigation up to the 150th day after the cryo-injury to shed light on the natural history of the ulcer healing process compared with developmental changes of postnatal fundic glands. By the 30th day, restitutive gastric glands were mostly seen to cover the ulcer lesions, where well-developed gland-type mucous cells, showing Griffonia simplicifolia agglutinin (GSA)-II labeling, appeared to occupy the basal portion. Most of the bromodeoxyuridine-labeled cells were superimposed on the GSA-II-positive cell zone, forming the proliferative zone. By the 150th day, the restitutive glands were complete, with all epithelial components and topology of the normal fundic glands. The process of the ulcer healing was quite compatible with the developmental changes of the postnatal fundic glands. These results imply that the regeneration of gastric epithelium during the ulcer healing follows pathways linked to the ontogenetic course of the fundic gland.

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Acknowledgements

We are grateful to Soyuki Ide, Eiko Matsuura (Department of Anatomy, Miyazaki Medical College, University of Miyazaki) and Yoshiteru Goto (Division of Electron Microscopy, Central Research Laboratories, Miyazaki Medical College, University of Miyazaki) for their expert assistance and to Mr. H. K. Barman for his editorial reading. This research was supported by Grants-in-Aid for 21st Century COE Program (Life Science) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, for Scientific Research from the MEXT of Japan (08670024), and from the Japan Society for the Promotion of Science (1370019).

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  1. Department of Anatomy, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, 889-1692, Miyazaki , Japan

    Ryoko Nagaike, Akira Sawaguchi, Jun-ichi Kawano, Fumiyo Aoyama, Tsutomu Oinuma & Tatsuo Suganuma

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  1. Ryoko Nagaike
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  2. Akira Sawaguchi
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  3. Jun-ichi Kawano
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  4. Fumiyo Aoyama
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  5. Tsutomu Oinuma
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  6. Tatsuo Suganuma
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Correspondence to Tatsuo Suganuma.

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Nagaike, R., Sawaguchi, A., Kawano, Ji. et al. Regeneration of gastric mucosa during ulcer healing follows pathways that correspond to the ontogenetic course of rat fundic glands. Virchows Arch 445, 580–588 (2004). https://doi.org/10.1007/s00428-004-1134-x

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  • DOI: https://doi.org/10.1007/s00428-004-1134-x

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