Virchows Archiv

, Volume 445, Issue 6, pp 545–551

CD10 expression in diffuse large B-cell lymphomas does not influence survival

  • Bettina Fabiani
  • Alain Delmer
  • Eric Lepage
  • Catherine Guettier
  • Tony Petrella
  • Josette Brière
  • Anne-Marie Penny
  • Marie-Christine Copin
  • Jacques Diebold
  • Felix Reyes
  • Philippe Gaulard
  • Thierry J. Molina
  • Groupe d’Etudes des Lymphomes de l’Adulte
Original Article

DOI: 10.1007/s00428-004-1129-7

Cite this article as:
Fabiani, B., Delmer, A., Lepage, E. et al. Virchows Arch (2004) 445: 545. doi:10.1007/s00428-004-1129-7

Abstract

CD10 expression is considered as a marker of centrofollicular-derived diffuse large B-cell lymphomas (DLBCL). The aim of our study was to determine retrospectively among 98 patients with DLBCL, enrolled in the LNH93 trial of the Groupe d’Etude des Lymphomes de l’Adulte (GELA) and homogeneously treated with high-dose cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)-like regimen [doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP)], the expression of CD10 using immunohistochemistry and its correlation with morphological features and clinical parameters. Of the 98 patients studied, 33 (34%) expressed CD10. There was no correlation among clinical parameters, International Prognostic Index risk groups and CD10 expression, with the exception of lactic dehydrogenase levels, which were lower in CD10-negative cases (P=0.005). There was no significant correlation between CD10 expression and morphological subtyping of DLBCL. Indeed, centrofollicular-derived DLBCL may present with numerous immunoblasts or as an immunoblastic lymphoma. Overall survival rate and event-free survival were not significantly different according to CD10 expression (P=0.44 and P=0.34 respectively). Therefore, it appears that CD10 expression does not influence survival or event-free survival in DLBCL.

Keywords

Lymphoma Tumor marker Clinical pathology 

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Bettina Fabiani
    • 1
  • Alain Delmer
    • 2
  • Eric Lepage
    • 3
  • Catherine Guettier
    • 4
  • Tony Petrella
    • 5
  • Josette Brière
    • 6
  • Anne-Marie Penny
    • 7
  • Marie-Christine Copin
    • 8
  • Jacques Diebold
    • 9
  • Felix Reyes
    • 10
  • Philippe Gaulard
    • 11
  • Thierry J. Molina
    • 9
  • Groupe d’Etudes des Lymphomes de l’Adulte
  1. 1.Département de PathologieHôpital Saint-Antoine, AP-HPParisFrance
  2. 2.Service d’Hématologie cliniqueHôpital Hôtel-Dieu, AP-HPParisFrance
  3. 3.Département de Biostatistiques et Informatique MédicaleHôpital Henri-Mondor, AP-HPCréteilFrance
  4. 4.Département de PathologieHôpital Paul Brousse, AP-HPVillejuifFrance
  5. 5.Département de PathologieFaculté de MédecineDijonFrance
  6. 6.Département de PathologieHôpital Saint-Louis, AP-HPParisFrance
  7. 7.Service d’Hématologie CliniqueCentre François BaclesseCaenFrance
  8. 8.Département de PathologieHôpital CalmetteLilleFrance
  9. 9.Department of PathologyHôtel-Dieu, AP-HPParis Cedex 04France
  10. 10.Service d’Hématologie CliniqueHôpital Henri Mondor, AP-HPCréteilFrance
  11. 11.Département de PathologieHôpital Henri Mondor, AP-HPCréteilFrance

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