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Virchows Archiv

, Volume 443, Issue 2, pp 220–221 | Cite as

Conventional renal cell carcinoma with granulomatous reaction: a report of three cases

  • Ondrej Hes
  • Milan Hora
  • Tomas Vanecek
  • Radek Sima
  • Miroslav Sulc
  • Frantisek Havlicek
  • Milena Beranova
  • Michal Michal
Letter to the Editor

Sir, we report three cases of conventional renal cell carcinomas (CRCC) with granulomatous reaction occurring in the tumorous stroma. The patients were two women and one man aged from 73 years to 85 years (mean 78.3 years). All patients were treated only by nephrectomy. Tumours were well circumscribed, yellow to tan coloured with haemorrhagic foci. The size of the tumours ranged between 2.3 cm and 7.0 cm (mean 4.4 cm). Stage was pT1N0M0 in all cases according to the World Health Organization (WHO) 1998 staging system. Grossly, no features of necrosis were observed.

Histologically, all tumours were typical CRCC composed mainly of clear cells. All CRCCs were of Fuhrman 1. Granulomas were characterised by multinucleated giant cells without necrosis. They were irregularly dispersed within the tumorous stroma (Fig.  1). The amount of lymphoid admixture within granulomas varied from sparse (Fig.  2a) to heavy (Fig.  2b). In one case, we have found a small amount of granulomas within the normal...

Keywords

Conventional renal cell carcinoma Granulomatous response Non-caseating granulomas 

Notes

Acknowledgements

This study was supported by grant GA CR reg. no. 301/02/1232.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Ondrej Hes
    • 1
  • Milan Hora
    • 2
  • Tomas Vanecek
    • 1
  • Radek Sima
    • 1
  • Miroslav Sulc
    • 3
  • Frantisek Havlicek
    • 1
  • Milena Beranova
    • 4
  • Michal Michal
    • 1
  1. 1.Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty HospitalCharles's University HospitalPilsenCzech Republic
  2. 2.Department of UrologyCharles's University HospitalPilsenCzech Republic
  3. 3.Regional HospitalChomutovCzech Republic
  4. 4.Department of Obstetrics and GynecologyCharles's University HospitalPilsenCzech Republic

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