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Virchows Archiv

, Volume 441, Issue 6, pp 622–628 | Cite as

Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type

  •  A. Saxena
  •  K. Dyker
  •  S. Angel
  •  O. Moshynska
  •  S. Dharampaul
  •  D. Cockroft
Case Report

Abstract.

The exact relationship between lymphomatoid granulomatosis (LyG) and posttransplant lymphoproliferative disorders (PTLDs) is not clear. Both are observed in immunodeficient patients and are Epstein-Barr virus driven. These disorders are, however, considered distinct based upon the immune response elicited; LyG is T-cell rich while PTLDs are T-cell poor. We describe a case of LyG-type diffuse large B-cell lymphoma (DLBCL) in a lung transplant recipient. The unusual features include rare occurrence of LyG in a posttransplant setting, systemic involvement by LyG variant of DLBCL in a solid organ transplant recipient, paucity of T-cells in this LyG type lymphoma, and subcutaneous panniculitic pattern in a B-cell lymphoproliferative disorder. This first report of systemic LyG variant of DLBCL in a posttransplant setting has features suggesting similarities and overlap between LyG and PTLD.

Posttransplant lymphoproliferative disorder Diffuse large B-cell lymphoma lymphomatoid granulomatosis variant Panniculitic B-cell lymphoma Angiocentric lymphoma Epstein-Barr virus 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  •  A. Saxena
    • 1
  •  K. Dyker
    • 1
  •  S. Angel
    • 1
  •  O. Moshynska
    • 1
  •  S. Dharampaul
    • 2
  •  D. Cockroft
    • 3
  1. 1.Department of Pathology, Royal University Hospital, 103 Hospital Drive, Saskatoon SK S7 N OW8, Canada
  2. 2.Department of Radiology, Royal University Hospital, 103 Hospital Drive, Saskatoon SK S7 N OW8, Canada
  3. 3.Department of Internal Medicine, Royal University Hospital, 103 Hospital Drive, Saskatoon SK S7 N OW8, Canada

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