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Virchows Archiv

, Volume 440, Issue 4, pp 376–380 | Cite as

High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma

  • Masaki Miyamoto
  • Ken Haruma
  • Toru Hiyama
  • Tomoari Kamada
  • Hiroshi Masuda
  • Fumio Shimamoto
  • Kazuhiko Inoue
  • Kazuaki Chayama
Original Article

Abstract

Many studies have indicated a close association between gastric mucosa-associated lymphoid tissue (MALT) lymphoma and Helicobacter pylori (Hp) infection. Follicular gastritis (FG), a rare type of gastritis, is also closely associated with Hp infection and histologically similar to MALT lymphoma. However, there are few studies investigating the relationship between FG and MALT lymphoma. To clarify the issue, we examined the B-cell monoclonality in FG by immunoglobulin heavy chain (IgH) gene rearrangement. Seventy FG patients (all Hp-positive, 23 males and 47 females, median age 33 yr) were investigated; 70 age-and gender-matched non-FG Hp-positive controls and 24 non-FG Hp-negative controls were also examined. Two gastric biopsies, one from the antrum and one from the corpus, were obtained from each patient. DNA was extracted from formalin-fixed, paraffin-embedded biopsy specimens. IgH gene rearrangement was examined by semi-nested polymerase chain reaction (PCR). In the antral mucosa, monoclonal B-cell populations were detected in 19 (32%) of 60 FG, in 6 (10%) of 60 Hp-positive controls, and in none of 20 Hp-negative controls. In the corporal mucosa, monoclonal B-cell populations were detected in 14 (30%) of 47 FG, in 6 (11%) of 54 Hp-positive controls, and in none of 20 Hp-negative controls. The incidence of monoclonal B-cell populations in the FG patients was higher than in both Hp-positive and Hp-negative controls (P<0.05). The monoclonal B-cell populations disappeared after successful Hp eradication in 8 of 8 FG patients examined. These data suggest that FG may be strongly associated with MALT lymphoma, and that Hp eradication therapy may be indicated in FG.

Follicular gastritis Immunoglobulin heavy chain B-cell monoclonality PCR 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Masaki Miyamoto
    • 1
  • Ken Haruma
    • 2
  • Toru Hiyama
    • 1
  • Tomoari Kamada
    • 1
  • Hiroshi Masuda
    • 1
  • Fumio Shimamoto
    • 3
  • Kazuhiko Inoue
    • 4
  • Kazuaki Chayama
    • 1
  1. 1.First Department of Internal Medicine, Hiroshima University School of Medicine, HiroshimaJapan
  2. 2.Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192Japan
  3. 3.Department of Anatomical Pathology, Hiroshima University Hospital, HiroshimaJapan
  4. 4.Department of Internal Medicine, Matsue Red Cross Hospital, MatsueJapan

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