Virchows Archiv

, Volume 440, Issue 2, pp 139–144

Expression of the adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) in breast cancer is associated with the expression of the tumor-suppressor genes Rb, Rb2, and p27

  • Ana-Maria Bamberger
  • Holger Kappes
  • Carola Methner
  • Gabriele Rieck
  • Jens Brümmer
  • Christoph Wagener
  • Thomas Löning
  • Karin Milde-Langosch
Original Article

DOI: 10.1007/s00428-001-0554-0

Cite this article as:
Bamberger, AM., Kappes, H., Methner, C. et al. Virchows Arch (2002) 440: 139. doi:10.1007/s00428-001-0554-0

Abstract.

The adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) is not only involved in maintaining normal tissue architecture, but also acts as a tumor suppressor in several experimental systems where loss of CEACAM1 expression results in enhanced tumor-cell growth and tumorigenicity. In order to further analyze the role of CEACAM1 in the development of breast cancer, we performed Western-blot analysis and immunohistochemistry with highly specific monoclonal antibodies in a cohort of 68 mammary carcinomas which had also been analyzed for expression of cell-cycle regulatory proteins cyclin D1, cyclin E, p16, p21, p27, Rb, and Rb2, as well as for steroid hormone receptor status, Ki67, and HER2/neu immunoreactivity. High CEACAM1 protein expression as found using both methods correlated significantly with expression of the retinoblastoma proteins Rb (P=0.004 and 0.013) and Rb2/p130 (P=0.003 and 0.007). In addition, we found a weak association of CEACAM1 expression with p27 protein levels (P=0.087 and 0.039), but with none of the other analyzed parameters. These results indicate the possibility of a functional link between cell-adhesion molecules and cell-cycle regulation that might play an important role in the development of mammary carcinomas.

CEACAM1 Cell-cycle proteins Rb Rb2 P27 Breast cancer 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Ana-Maria Bamberger
    • 1
  • Holger Kappes
    • 1
  • Carola Methner
    • 1
  • Gabriele Rieck
    • 1
  • Jens Brümmer
    • 2
  • Christoph Wagener
    • 2
  • Thomas Löning
    • 1
  • Karin Milde-Langosch
    • 1
  1. 1.Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, GermanyGermany
  2. 2.Department of Clinical Chemistry, University Hospital Eppendorf, Martinistr. 52, 20246 Hamburg, GermanyGermany

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