Virchows Archiv

, Volume 440, Issue 5, pp 485–490

Translocation of the HMGI-C (HMGA2) gene in a benign mesenchymoma (chondrolipoangioma)

  • Jo Van Dorpe
  • Paola Dal Cin
  • Stanislawa Weremowicz
  • Fred Van Leuven
  • Ivo de Wever
  • Herman Van den Berghe
  • Christopher Fletcher
  • Raf Sciot
Original Article
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Abstract.

Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However, using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene (HMGI-C; HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.

Chondrolipoangioma Cartilage-containing benign mesenchymoma Fluorescence in situ hybridization Conventional cytogenetic analysis HMGI-C HMGA2 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Jo Van Dorpe
    • 1
  • Paola Dal Cin
    • 4
  • Stanislawa Weremowicz
    • 4
  • Fred Van Leuven
    • 3
  • Ivo de Wever
    • 5
  • Herman Van den Berghe
    • 3
  • Christopher Fletcher
    • 4
  • Raf Sciot
    • 1
  1. 1.Department of Pathology, University Hospital St.-Raphaël, Katholieke Universiteit Leuven, Minderbroedersstraat 12, 3000 Leuven, BelgiumBelgium
  2. 2.Department of Pathology, AZ VUB Jette, Laarbeeklaan 101, 1090 Brussels, BelgiumBelgium
  3. 3.Center for Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O & N, Leuven, BelgiumBelgium
  4. 4.Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USAUSA
  5. 5.Surgical Oncology, University Hospitals, Katholieke Universiteit Leuven, Leuven, BelgiumBelgium

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