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Development Genes and Evolution

, Volume 209, Issue 6, pp 370–375 | Cite as

Distinct expression patterns of different Enhancer of split bHLH genes during embryogenesis of Drosophilamelanogaster

  • Irmgard Wech
  • Sarah Bray
  • Christos Delidakis
  • A. Preiss
Short Communication

Abstract

E(spl) bHLH genes are targets of the Notch pathway: they are transcriptionally activated in response to the Notch signal. Yet, during imaginal development, additional regulatory factors appear to modulate transcription resulting in different expression patterns. During early embryogenesis all E(spl) bHLH genes are expressed in roughly the same domain, namely the neurogenic ectoderm. Within this region these seven genes show a highly dynamic, yet distinct transcriptional activity. Our analysis further detected tissue specific expression of some E(spl) genes at later embryonic stages. Prominent differences were observed in the dorsolateral and procephalic neuroectodermal regions as well as in the mesoderm. These observations indicate that other factors in addition to the Notch signal participate in the regulation of the individual E(spl) genes not only in imaginal tissues but also during neuroblast specification and other cell fate determination events in the embryo.

Key words bHLH genes Drosophila Embryogenesis Enhancer of split Notch pathway 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Irmgard Wech
    • 1
  • Sarah Bray
    • 2
  • Christos Delidakis
    • 3
  • A. Preiss
    • 1
  1. 1.Universität Hohenheim, Institut für Genetik (240), D-70593 Stuttgart, Germany E-mail: preiss@uni-hohenheim.de Tel.: +49-711-4592206, Fax: +49-711-4592211DE
  2. 2.Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UKGB
  3. 3.Institute of Molecular Biology and Biotechnology, FORTH, and Department of Biology, University of Crete, Heraklion, GreeceGR

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