Lbx1 expression and frog limb development
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In order to identify prospective limb muscle cells in a frog, we cloned Lbx1 from the direct developing frog Eleutherodactylus coqui. Like in embryos of the frog Xenopus laevis but unlike in other vertebrates, EcLbx1 is expressed in all trunk somites. Like in embryos of chick, mouse, and zebrafish, cells expressing EcLbx1 are then found in limb buds, consistent with migration of those cells from somites. EcLbx1 is also expressed in the dorsal spinal cord as in other vertebrates.
KeywordsDirect development Eleutherodactylus coqui Muscle, leg Somite Anuran amphibian
This work was supported by grant IOB-0343403 from the National Science Foundation (US) and grant 1R15HD059070-01 from the National Institute of Child Health and Human Development (NIH).