Development Genes and Evolution

, Volume 217, Issue 6, pp 477–483

Cloning and developmental expression of the Xenopus Nkx6 genes

Short Communication

DOI: 10.1007/s00427-007-0155-2

Cite this article as:
Zhao, S., Jiang, H., Wang, W. et al. Dev Genes Evol (2007) 217: 477. doi:10.1007/s00427-007-0155-2

Abstract

The evolutionarily conserved Nkx6 family transcription factors play important roles in the patterning of the central nervous system (CNS) and pancreas in vertebrates. In this study, we describe the cloning and expression patterns of the three Nkx6 family genes in Xenopus laevis. Like their mouse and chicken homologues, Xenopus Nkx6 family genes are mainly expressed in the CNS and anterior endodermal tissues during embryonic development. Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 is detected in the non-neural ectoderm from cleavage to early neurula stages and in the caudal hindbrain and the mandibular arch at tail bud stages. In the endoderm, Nkx6.2 is expressed in the hypochord at tail bud stages. At tadpole stages, the three Nkx6 genes are differentially expressed in the anterior endoderm derivatives, including the pancreas, stomach, esophagus, and lung.

Keywords

Nkx6 Xenopus Expression pattern Central nervous system Pancreas 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Shuhua Zhao
    • 1
    • 3
  • Huifeng Jiang
    • 2
    • 3
  • Wen Wang
    • 2
  • Bingyu Mao
    • 1
    • 4
  1. 1.CAS-Max Planck Junior Scientist Group on Neural Patterning, Key Laboratory of Cellular and Molecular EvolutionKunming Institute of Zoology, Chinese Academy of SciencesKunmingPeople’s Republic of China
  2. 2.CAS-Max Planck Junior Scientist Group on Evolutionary Genomics, Key Laboratory of Cellular and Molecular EvolutionKunming Institute of Zoology, Chinese Academy of SciencesKunmingPeople’s Republic of China
  3. 3.Graduate University of Chinese Academy of SciencesBeijingPeople’s Republic of China
  4. 4.Kunming Institute of ZoologyKunmingPeople’s Republic of China

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