Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera
- First Online:
- 72 Downloads
Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. Differences in the spatial expression of the proneural gene scute correlate with the positions of bristles in those species looked at so far. However, the examination of a number of genes encoding trans-regulatory factors, such as pannier, stripe, u-shaped, caupolican and wingless, indicates that they are expressed in conserved domains on the prospective notum. This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera, and that many differences are likely to be due to changes in cis-regulatory sequences of scute. In contrast, in Anopheles gambiae, a basal species with no stereotyped bristle pattern, the expression patterns of pannier and wingless are not conserved, and expression of AgASH, the Anopheles proneural gene, does not correlate in a similar manner with the bristle pattern. We discuss the possibility that independently acting cis-regulatory sequences at the scute locus may have arisen in the lineage giving rise to cyclorraphous flies.
KeywordsDrosophila Calliphora vicina Anopheles gambiae Achaete–scute Bristle pattern
- Lewis MA (2005) Characterisation of regulatory factors of achaete–scute in Anopheles gambiae. Ph.D. thesis, University of CambridgeGoogle Scholar
- McAlpine JF (1981) Manual of nearctic diptera. Research Branch, Agriculture Canada, OttawaGoogle Scholar
- Tiegs O (1955) The flight muscles of insects—their anatomy and histology; with some observations on the structure of striated muscle in general. Philos Trans R Soc Lond B Biol Sci 238:221–359Google Scholar