Development Genes and Evolution

, Volume 213, Issue 8, pp 412–415 | Cite as

Identification of the Drosophila melanogaster homolog of the human spastin gene

  • Lars KammermeierEmail author
  • Jürg Spring
  • Michael Stierwald
  • Jean-Marc Burgunder
  • Heinrich Reichert
Expression Note


The human SPG4 locus encodes the spastin gene, which is responsible for the most prevalent form of autosomal dominant hereditary spastic paraplegia (AD-HSP), a neurodegenerative disorder. Here we identify the predicted gene product CG5977 as the Drosophila homolog of the human spastin gene, with much higher sequence similarities than any other related AAA domain protein in the fly. Furthermore we report a new potential transmembrane domain in the N-terminus of the two homologous proteins. During embryogenesis, the expression pattern of Drosophila spastin becomes restricted primarily to the central nervous system, in contrast to the ubiquitous expression of the vertebrate spastin genes. Given this nervous system-specific expression, it will be important to determine if Drosophila spastin loss-of-function mutations also lead to neurodegeneration.


Drosophila melanogaster Spastin AAA domain Embryonic CNS 



We thank Boris Egger, Simon Sprecher, and Urs Stiefel for technical assistance, and Bruno Bello, Frank Hirth and Ronny Leemans for comments on the manuscript. This work was supported by the Swiss NSF.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Lars Kammermeier
    • 1
    Email author
  • Jürg Spring
    • 1
  • Michael Stierwald
    • 1
  • Jean-Marc Burgunder
    • 2
  • Heinrich Reichert
    • 1
  1. 1.Institute of Zoology, Biozentrum/PharmazentrumUniversity of BaselBaselSwitzerland
  2. 2.National University of Singapore and National Neuroscience InstituteSingaporeSingapore

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