Complementary expression of AP-2 and AP-2rep in ectodermal derivatives of Xenopus embryos
- First Online:
- Cite this article as:
- Gotoh, M., Izutsu, Y. & Maéno, M. Dev Genes Evol (2003) 213: 363. doi:10.1007/s00427-003-0336-6
- 41 Downloads
In an attempt to define the pattern of developmental expression of AP-2rep and AP-2 in Xenopus embryos, we cloned a Xenopus AP-2rep cDNA. The AP-2rep message was localized in the organizer region at the gastrula stage whereas AP-2 was expressed ventro-laterally in the animal hemisphere. Later, AP-2rep was expressed in the entire neural tissue at the neurula stage while AP-2 was predominantly expressed in the cranial neural crest areas. The endogenous expression of AP-2 in the neural crest area was diminished by ectopic injection of AP-2rep RNA, suggesting a role for AP-2rep in the differentiation of neural tissues by restricting the expression of AP-2 in the Xenopus embryo.