, Volume 249, Issue 1, pp 181–193 | Cite as

Bio-solar cell factories for photosynthetic isoprenoids production

  • Sung Cheon Ko
  • Hyun Jeong Lee
  • Sun Young Choi
  • Jong-il Choi
  • Han Min WooEmail author
Part of the following topical collections:
  1. Terpenes and Isoprenoids


Main conclusion

Photosynthetic production of isoprenoids in cyanobacteria is considered in terms of metabolic engineering and biological importance.

Metabolic engineering of photosynthetic bacteria (cyanobacteria) has been performed to construct bio-solar cell factories that convert carbon dioxide to various value-added chemicals. Isoprenoids, which are found in nature and range from essential cell components to defensive molecules, have great value in cosmetics, pharmaceutics, and biofuels. In this review, we summarize the recent engineering of cyanobacteria for photosynthetic isoprenoids production as well as carbon molar basis comparisons with heterotrophic isoprenoids production in engineered Escherichia coli.


Isoprenoid Terpene CO2 conversion Cyanobacteria Metabolic engineering 



Isopentenyl diphosphate


Dimethylallyl pyrophosphate


Methylerythritol 4-phosphate




Geranyl diphosphate


Farnesyl diphosphate


Geranylgeranyl diphosphate


Dry cell weight

PCC 6803

Synechocystis sp. PCC 6803

PCC 7942

Synechococcus elongatus PCC 7942

PCC 7120

Anabaena sp. PCC 7120

PCC 7002

Synechococcus sp. PCC 7002



The authors thank Prof. Sang Jun Sim at Korea University and Prof. EonSon Jin at Hanyang University for valuable discussion.


This work was supported by Korea CCS R&D Center (KCRC) (2017M1A8A1072034) and Basic Science Research Program (2017R1A2B2002566) through the National Research Foundation of Korea, funded by the Korean Government (Ministry of Science and ICT). In addition, this work was partially supported by the Golden Seed Project (213008-05-1-WT911) grant, funded by the Ministry of Agriculture and the Ministry of Oceans and Fisheries.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics of approval and consent to participate

Not applicable.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Food Science and BiotechnologySungkyunkwan University (SKKU)SuwonRepublic of Korea
  2. 2.Department of Biotechnology and BioengineeringChonnam National UniversityGwangjuRepublic of Korea

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