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Pflügers Archiv

, Volume 435, Issue 5, pp 583–594 | Cite as

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1

  • J. Gromada
  • Jens Juul Holst
  • Patrik Rorsman
INVITED REVIEW

Abstract

 Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-induced pancreatic hormone release. GLP-1 modulates insulin, glucagon and somatostatin secretion by binding to guanine nucleotide binding protein-coupled receptors resulting in the activation of adenylate cyclase and generation of cyclic adenosine monophosphate (cAMP). In the B-cell, cAMP, via activation of protein kinase A, interacts with a plethora of signal transduction processes including ion channel activity, intracellular Ca2+ handling and exocytosis of the insulin-containing granules. The stimulatory action of GLP-1 on insulin secretion, contrary to that of the currently used hypoglycaemic sulphonylureas, is glucose dependent and requires the presence of normal or elevated concentrations of the sugar. For this reason, GLP-1 attracts much interest as a possible novel principle for the treatment of human type-2 diabetes. Here we review the actions of GLP-1 on islet cell function and attempt to integrate current knowledge into a working model for the control of pancreatic hormone secretion.

Key words GLP-1 cAMP Insulin Calcium NIDDM Glucagon Islet GIP 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J. Gromada
    • 1
  • Jens Juul Holst
    • 2
  • Patrik Rorsman
    • 3
  1. 1.Department of Islet Cell Physiology, Novo Nordisk A/S, The Symbion Science Park, Fruebjergvej 3, DK-2100 Copenhagen, DenmarkDK
  2. 2.Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, DenmarkDK
  3. 3.Department of Physiology and Neuroscience, University of Lund, Sölvegatan 19, S-223 62, Lund, SwedenSE

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