Pflügers Archiv

, Volume 431, Issue 6, pp 863–867 | Cite as

Systemic filling pressure in the intact circulation determined with a slow inflation procedure

  • E. A. den Hartog
  • J. R. C. Jansen
  • G. H. Moens
  • A. Versprille
Original Article


In eight mechanically ventilated, anaesthetized pigs weighing 10.3 ± 0.8 kg (mean ± SD) we studied the effect of the inflation time of the lung on the estimation of the mean systemic filling pressure (@#@ Psf) from the changes in venous return and central venous pressure during inflation of the lung. For this purpose we applied slow inflation procedures (SIP) to the lung with inflation times of 2.4, 4.8, 7.2, 9.6 and 12 s at tidal volumes (VT) of 15 and 30 ml/kg. The data were compared with the values of Psf obtained from inspiratory pause procedures (IPPs). A linear regression between venous return and central venous pressure applied during a SIP underestimated Psf compared with the value obtained with IPPs. An exponential fit through the values of Psf obtained from the different SIPs predicted an inflation time of about 15 s for an estimation of Psf that is not different from the Psf (IPP). The advantage of the SIP method is that the Psf can be determined much faster than with the method based on IPPs. However, due to the rather long inflation time needed, the method may be only applicable under circumstances where neurohumoral control mechanisms are suppressed as during intensive care and anaesthesia.

Key words

Venous return Central venous pressure Inspiratory pause procedures Venous capacity Venous resistance Mechanical ventilation 


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  1. 1.
    Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet i: 307–310Google Scholar
  2. 2.
    Fessier HE, Brower RG, Wise RA, Permutt S (1992) Effects of positive end-expiratory pressure on the canine venous return curve. Am Rev Respir Dis 146:4–10Google Scholar
  3. 3.
    Guyton AC, Jones CE, Coleman TG (1973) Circulatory physiology: cardiac output and its regulation. Saunders, PhiladelphiaGoogle Scholar
  4. 4.
    Guyton AC, Lindsey AW, Kaufmann BN (1955) Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180:463–468PubMedGoogle Scholar
  5. 5.
    Hartog EA den, Versprille A, Jansen JRC (1994) Systemic filling pressure in intact circulation on basis of aortic vs. central venous pressure relationships. Am J Physiol 267: H2255-H2258Google Scholar
  6. 6.
    Jansen JRC, Hoorn E, Goudoever J van, Versprille A (1989) A computerized respiratory system including test functions of lung and circulation. J Appl Phys 67:1687–1691Google Scholar
  7. 7.
    Pinsky MR (1984) Instantaneous venous return curves in an intact canine preparation. J Appl Physiol 56:765–771PubMedGoogle Scholar
  8. 8.
    Versprille A (1990) The pulmonary circulation during mechanical ventilation. Acta Anaesthesiol Scand 34 (Suppl 94): 51–62CrossRefGoogle Scholar
  9. 9.
    Versprille A, Jansen JRC (1985) Mean systemic filling pressure as a characteristic pressure for venous return. Pflugers Arch 405:226–233PubMedCrossRefGoogle Scholar
  10. 10.
    Versprille A, Jansen JRC, Frietman RC, Hulsmann AR, Klauw MM van der (1990) Negative effect of insufflation on cardiac output and pulmonary blood volume. Acta Anaesthesiol Scand 34:607–615PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • E. A. den Hartog
    • 1
  • J. R. C. Jansen
    • 1
  • G. H. Moens
    • 1
  • A. Versprille
    • 1
  1. 1.Pathophysiology Laboratory, Department of Pulmonary DiseasesErasmus UniversityDR RotterdamThe Netherlands

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