Physiome approach for the analysis of vascular flow reserve in the heart and brain

  • Kyung Eun Lee
  • Ah-Jin Ryu
  • Eun-Seok Shin
  • Eun Bo ShimEmail author
Invited Review


This work reviews the key aspects of coronary and neurovascular flow reserves with an emphasis on physiomic modeling characteristics by the use of a variety of numerical approaches. First, we explain the definition of fractional flow reserve (FFR) in coronary artery and introduce its clinical significance. Then, computational researches for obtaining FFR are reviewed, and their clinical outcomes are compared. In the case of cerebrovascular reserve (CVR), in spite of substantial progress in the simulation of cerebral hemodynamics, only a few computational studies exist. Thus, we discuss the limitations of CVR simulation study and suggest the challenging issue to overcome these. Also, the future direction of physiomic researches for the flow reserves in coronary arteries and cerebral arteries is described. Also, we introduce a machine learning algorithm trained by the existing physiomic simulation data of flow reserve and suggest a prospective research direction related to this.


Flow reserve Coronary artery Cerebrovascular system Physiomic approach 



The authors thank all our lab members for their supports. And we thank the anonymous reviewers and editors for their valuable comments.

Authors’ contributions

KE Lee, AJ Ryu, ES Shin, and EB Shim all participated in the study. All authors read and approved the final manuscript.

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

The data is deposited in Biosystems Engineering Lab of Kangwon National University. Please contact the correspondence author Eun Bo Shim,, for the usage of data.

Ethics approval and consent to participate

The subjects all gave their written informed consent in accordance with local ethics committee of Kangwon National University.

The data used in this research has been approved by the ethics committee of Kangwon National University.


This work was supported by the National Research foundation of Korea (NRF) grant (NRF-2015R1A2A1A0100774).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Kyung Eun Lee
    • 1
  • Ah-Jin Ryu
    • 1
  • Eun-Seok Shin
    • 2
  • Eun Bo Shim
    • 1
    Email author
  1. 1.Department of Mechanical and Biomedical EngineeringKangwon National UniversityChuncheon-siRepublic of Korea
  2. 2.Department of CardiologyUniversity of Ulsan College of MedicineUlsanSouth Korea

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