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Pflügers Archiv - European Journal of Physiology

, Volume 468, Issue 8, pp 1449–1458 | Cite as

Estimation of the flow resistances exerted in coronary arteries using a vessel length-based method

  • Kyung Eun Lee
  • Soon-Sung Kwon
  • Yoon Cheol Ji
  • Eun-Seok Shin
  • Jin-Ho Choi
  • Sung Joon Kim
  • Eun Bo ShimEmail author
Muscle physiology

Abstract

Flow resistances exerted in the coronary arteries are the key parameters for the image-based computer simulation of coronary hemodynamics. The resistances depend on the anatomical characteristics of the coronary system. A simple and reliable estimation of the resistances is a compulsory procedure to compute the fractional flow reserve (FFR) of stenosed coronary arteries, an important clinical index of coronary artery disease. The cardiac muscle volume reconstructed from computed tomography (CT) images has been used to assess the resistance of the feeding coronary artery (muscle volume-based method). In this study, we estimate the flow resistances exerted in coronary arteries by using a novel method. Based on a physiological observation that longer coronary arteries have more daughter branches feeding a larger mass of cardiac muscle, the method measures the vessel lengths from coronary angiogram or CT images (vessel length-based method) and predicts the coronary flow resistances. The underlying equations are derived from the physiological relation among flow rate, resistance, and vessel length. To validate the present estimation method, we calculate the coronary flow division over coronary major arteries for 50 patients using the vessel length-based method as well as the muscle volume-based one. These results are compared with the direct measurements in a clinical study. Further proving the usefulness of the present method, we compute the coronary FFR from the images of optical coherence tomography.

Keywords

Estimation of coronary resistances Vessel length-based method Coronary fractional flow reserve 

Notes

Acknowledgments

This research was supported by the R&D program of MSIP/COMPA (2015K000245, Development of high-level simulation model of stenosed coronary artery) and the National Research Foundation of Korea (NRF) grants (NRF-2015R1A2A1A0100774).

Compliance with ethical standards

All the human data used in this study were from Ulsan University Hospital, and their use was approved by the IRB of the institution

Competing interests

The authors declared that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Kyung Eun Lee
    • 1
  • Soon-Sung Kwon
    • 1
  • Yoon Cheol Ji
    • 1
  • Eun-Seok Shin
    • 2
  • Jin-Ho Choi
    • 3
  • Sung Joon Kim
    • 4
  • Eun Bo Shim
    • 1
    Email author
  1. 1.Department of Mechanical and Biomedical EngineeringKangwon National UniversityChuncheonRepublic of Korea
  2. 2.Department of CardiologyUniversity of Ulsan College of MedicineUlsanRepublic of Korea
  3. 3.Department of Internal MedicineSungkyunkwan University School of MedicineSeoulRepublic of Korea
  4. 4.Department of PhysiologySeoul National University College of MedicineSeoulRepublic of Korea

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