Abstract
Pancreatic ductal epithelial cells play a fundamental role in HCO3 − secretion, a process which is essential for maintaining the integrity of the pancreas. Although several studies have implicated impaired HCO3 − and fluid secretion as a triggering factor in the development of pancreatitis, the mechanism and regulation of HCO3 − secretion is still not completely understood. To date, most studies on the ion transporters that orchestrate ductal HCO3 − secretion have focussed on the role of Cl−/HCO3 − exchangers and Cl− channels, whereas much less is known about the role of K+ channels. However, there is growing evidence that many types of K+ channels are present in ductal cells where they have an essential role in establishing and maintaining the electrochemical driving force for anion secretion. For this reason, strategies that increase K+ channel function may help to restore impaired HCO3 − and fluid secretion, such as in pancreatitis, and therefore provide novel directions for future pancreatic therapy. In this review, our aims are to summarize the types of K+ channels found in pancreatic ductal cells and to discuss their individual roles in ductal HCO3 − secretion. We will also describe how K+ channels are involved in pathophysiological conditions and discuss how they could act as new molecular targets for the development of therapeutic approaches to treat pancreatic diseases.
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Acknowledgments
Our research is supported by Hungarian National Development Agency grants (TÁMOP-4.2.2.A-11/1/KONV-2012-0035, TÁMOP-4.2.2-A-11/1/KONV-2012-0052, TÁMOP-4.2.2.A-11/1/KONV-2012-0073), the Hungarian Scientific Research Fund (OTKA NF105758, NF100677, K109756) and the Hungarian Academy of Sciences (BO/00531/11/5). This research was also supported by the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4.A/2-11-1-2012-0001 ‘National Excellence Program’ and MTA-SZTE Momentum Grant (LP2014-10/2014).
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The authors hereby declare that there is no conflict of interest to disclose.
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Venglovecz, V., Rakonczay, Z., Gray, M.A. et al. Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance. Pflugers Arch - Eur J Physiol 467, 625–640 (2015). https://doi.org/10.1007/s00424-014-1585-0
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DOI: https://doi.org/10.1007/s00424-014-1585-0