Pflügers Archiv - European Journal of Physiology

, Volume 465, Issue 1, pp 153–165 | Cite as

Renal renin secretion as regulator of body fluid homeostasis

  • Mads Damkjær
  • Gustaf L. Isaksson
  • Jane Stubbe
  • Boye L. Jensen
  • Kasper Assersen
  • Peter Bie
Invited Review

Abstract

The renin–angiotensin system is essential for body fluid homeostasis and blood pressure regulation. This review focuses on the homeostatic regulation of the secretion of active renin in the kidney, primarily in humans. Under physiological conditions, renin secretion is determined mainly by sodium intake, but the specific pathways involved and the relations between them are not well defined. In animals, renin secretion is a log-linear function of sodium intake. Close associations exist between sodium intake, total body sodium, extracellular fluid volume, and blood volume. Plasma volume increases by about 1.5 mL/mmol increase in daily sodium intake. Several lines of evidence indicate that central blood volume may vary substantially without measurable changes in arterial blood pressure. At least five intertwining feedback loops of renin regulation are identifiable based on controlled variables (blood volume, arterial blood pressure), efferent pathways to the kidney (nervous, humoral), and pathways operating via the macula densa. Taken together, the available evidence favors the notion that under physiological conditions (1) volume-mediated regulation of renin secretion is the primary regulator, (2) macula densa mediated mechanisms play a substantial role as co-mediator although the controlled variables are not well defined so far, and (3) regulation via arterial blood pressure is the exception rather than the rule. Improved quantitative analyses based on in vivo and in silico models are warranted.

Keywords

Sodium intake Total body sodium Blood volume Blood pressure Macula densa 

Notes

Acknowledgments

The work of the authors has been supported by Novo Nordisk Foundation (PB), Danish Heart Association (PB), and the Danish Medical Research Council (GLI).

Reference

  1. 1.
    (1981) Geigy scientific tables: Units of measurement, body fluids, composition of the body, nutrition, vols. 1. Ciba-Geigy, BasleGoogle Scholar
  2. 2.
    Andersen LJ, Andersen JL, Pump B, Bie P (2002) Natriuresis induced by mild hypernatremia in humans. Am J Physiol Regul Integr Comp Physiol 282:R1754–R1761PubMedGoogle Scholar
  3. 3.
    Andersen JL, Andersen LJ, Thrasher TN, Keil LC, Ramsay DJ (1994) Left heart and arterial baroreceptors interact in control of plasma vasopressin, renin, and cortisol in awake dogs. Am J Physiol 266:R879–R888PubMedGoogle Scholar
  4. 4.
    Andersen LJ, Andersen JL, Thrasher TN, Keil LC, Ramsay DJ (1995) Effect of loading right atrial and ventricular receptors on stimulated AVP, ACTH, and renin secretion in awake dogs. Am J Physiol 268:R1069–R1077PubMedGoogle Scholar
  5. 5.
    Andersen LJ, Jensen TU, Bestle MH, Bie P (1999) Isotonic and hypertonic sodium loading in supine humans. Acta Physiol Scand 166:23–30PubMedGoogle Scholar
  6. 6.
    Andersen LJ, Jensen TU, Bestle MH, Bie P (2000) Gastrointestinal osmoreceptors and renal sodium excretion in humans. Am J Physiol Regul Integr Comp Physiol 278:R287–R294PubMedGoogle Scholar
  7. 7.
    Andersen LJ, Norsk P, Johansen LB, Christensen P, Engstrom T, Bie P (1998) Osmoregulatory control of renal sodium excretion after sodium loading in humans. Am J Physiol 275:R1833–R1842PubMedGoogle Scholar
  8. 8.
    Anderson CA, Appel LJ, Okuda N, Brown IJ, Chan Q, Zhao L et al (2010) Dietary sources of sodium in China, Japan, the United Kingdom, and the United States, women and men aged 40 to 59 years: the INTERMAP study. J Am Diet Assoc 110:736–745PubMedGoogle Scholar
  9. 9.
    Baltatu OC, Campos LA, Bader M (2011) Local renin–angiotensin system and the brain—a continuous quest for knowledge. Peptides 32:1083–1086PubMedGoogle Scholar
  10. 10.
    Bevegard S, Castenfors J, Lindblad LE (1977) Effect of changes in blood volume distribution on circulatory variables and plasma renin activity in man. Acta Physiol Scand 99:237–245PubMedGoogle Scholar
  11. 11.
    Bie P, Damkjaer M (2010) Renin secretion and total body sodium: pathways of integrative control. Clin Exp Pharmacol Physiol 37:e34–e42PubMedGoogle Scholar
  12. 12.
    Bie P, Molstrom S, Wamberg S (2009) Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade. Am J Physiol Regul Integr Comp Physiol 296:R428–R435PubMedGoogle Scholar
  13. 13.
    Braith RW, Mills RM Jr, Wilcox CS, Convertino VA, Davis GL, Limacher MC et al (1996) Fluid homeostasis after heart transplantation: the role of cardiac denervation. J Heart Lung Transplant 15:872–880PubMedGoogle Scholar
  14. 14.
    Braith RW, Mills RM, Wilcox CS, Davis GL, Hill JA, Wood CE (2003) High-dose angiotensin-converting enzyme inhibition restores body fluid homeostasis in heart-transplant recipients. J Am Coll Cardiol 41:426–432PubMedGoogle Scholar
  15. 15.
    Braith RW, Mills RM Jr, Wilcox CS, Davis GL, Wood CE (1996) Breakdown of blood pressure and body fluid homeostasis in heart transplant recipients. J Am Coll Cardiol 27:375–383PubMedGoogle Scholar
  16. 16.
    Brubacher ES, Vander AJ (1968) Sodium deprivation and renin secretion in unanesthetized dogs. Am J Physiol 214:15–21PubMedGoogle Scholar
  17. 17.
    Bull MB, Hillman RS, Cannon PJ, Laragh JH (1970) Renin and aldosterone secretion in man as influenced by changes in electrolyte balance and blood volume. Circ Res 27:953–960PubMedGoogle Scholar
  18. 18.
    Carmichael DJ, Sutters MS, Unwin RJ, Gordon D, Few J, James VH et al (1990) Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man. Clin Sci (Lond) 78:605–612Google Scholar
  19. 19.
    Carvalho JS, Cherkes JK (1982) Renin release by pentobarbital anesthesia in the rat: a role for vascular mechanisms. Life Sci 30:887–897PubMedGoogle Scholar
  20. 20.
    Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C (2010) Physiology of kidney renin. Physiol Rev 90:607–673PubMedGoogle Scholar
  21. 21.
    Cowley AW Jr, Liard JF, Guyton AC (1973) Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32:564–576PubMedGoogle Scholar
  22. 22.
    Cowley AW Jr, Lohmeier TE (1979) Changes in renal vascular sensitivity and arterial pressure associated with sodium intake during long-term intrarenal norepinephrine infusion in dogs. Hypertension 1:549–558PubMedGoogle Scholar
  23. 23.
    Cuneo RC, Espiner EA, Crozier IG, Yandle TG, Nicholls MG, Ikram H (1989) Chronic and acute volume expansion in normal man: effect on atrial diameter and plasma atrial natriuretic peptide. Horm Metab Res 21:148–151PubMedGoogle Scholar
  24. 24.
    Damgaard M, Gabrielsen A, Heer M, Warberg J, Bie P, Christensen NJ et al (2002) Effects of sodium intake on cardiovascular variables in humans during posture changes and ambulatory conditions. Am J Physiol Regul Integr Comp Physiol 283:R1404–R1411PubMedGoogle Scholar
  25. 25.
    Damgaard M, Norsk P, Gustafsson F, Kanters JK, Christensen NJ, Bie P et al (2006) Hemodynamic and neuroendocrine responses to changes in sodium intake in compensated heart failure. Am J Physiol Regul Integr Comp Physiol 290:R1294–R1301PubMedGoogle Scholar
  26. 26.
    Damkjaer M, Jacobsen IA, Hoilund-Carlsen PF, Bie P (2010) Hypernatriuresis in essential hypertension (Abstract). Acta Physiol Scand 198 (suppl. 677), Abstract number: O-TUE-3-7Google Scholar
  27. 27.
    Davis JO (1971) What signals the kidney to release renin? Circ Res 28:301–306PubMedGoogle Scholar
  28. 28.
    Denton DA (1982) Hunger for salt: An anthropological physiological and medical analysis. Springer-Verlag, New YorkGoogle Scholar
  29. 29.
    Denton D, Weisinger R, Mundy NI, Wickings EJ, Dixson A, Moisson P et al (1995) The effect of increased salt intake on blood pressure of chimpanzees. Nat Med 1:1009–1016PubMedGoogle Scholar
  30. 30.
    DiBona GF (1985) Neural regulation of renal tubular sodium reabsorption and renin secretion. Fed Proc 44:2816–2822PubMedGoogle Scholar
  31. 31.
    DiBona GF (2005) Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Comp Physiol 289:R633–R641PubMedGoogle Scholar
  32. 32.
    DiBona GF, Kopp UC (1997) Neural control of renal function. Physiol Rev 77:75–197PubMedGoogle Scholar
  33. 33.
    Doorenbos CJ, Iestra JA, Papapoulos SE, Odink J, Van BP (1990) Atrial natriuretic peptide and chronic renal effects of changes in dietary protein and sodium intake in man. Clin Sci (Lond) 78:565–572Google Scholar
  34. 34.
    Egan BM, Julius S, Cottier C, Osterziel KJ, Ibsen H (1983) Role of cardiovascular receptors on the neural regulation of renin release in normal men. Hypertension 5:779–786PubMedGoogle Scholar
  35. 35.
    Ehmke H, Persson P, Fischer S, Hackenthal E, Kirchheim H (1989) Resetting of pressure-dependent renin release by intrarenal alpha 1-adrenoceptors in conscious dogs. Pflügers Arch 413:261–266PubMedGoogle Scholar
  36. 36.
    Ehmke H, Persson P, Kirchheim H (1987) A physiological role for pressure-dependent renin release in long-term blood pressure control. Pflügers Arch 410:450–456PubMedGoogle Scholar
  37. 37.
    Epstein M (1992) Renal effects of head-out water immersion in humans: a 15-year update. Physiol Rev 72:563–621PubMedGoogle Scholar
  38. 38.
    Epstein M, Pins DS, Sancho J, Haber E (1975) Suppression of plasma renin and plasma aldosterone during water immersion in normal man. J Clin Endocrinol Metab 41:618–625PubMedGoogle Scholar
  39. 39.
    Finke R, Gross R, Hackenthal E, Huber J, Kirchheim HR (1983) Threshold pressure for the pressure-dependent renin release in the autoregulating kidney of conscious dogs. Pflügers Arch 399:102–110PubMedGoogle Scholar
  40. 40.
    Forman JP, Scheven L, de Jong PE, Bakker SJ, Curhan GC, Gansevoort RT (2012) Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertension. Circulation 125:3108–3116PubMedGoogle Scholar
  41. 41.
    Franco V, Oparil S (2006) Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival. J Am Coll Nutr 25:247S–255SPubMedGoogle Scholar
  42. 42.
    Gabrielsen A, Bie P, Holstein-Rathlou NH, Christensen NJ, Warberg J, Dige-Petersen H et al (2001) Neuroendocrine and renal effects of intravascular volume expansion in compensated heart failure. Am J Physiol Regul Integr Comp Physiol 281:R459–R467PubMedGoogle Scholar
  43. 43.
    Gabrielsen A, Pump B, Bie P, Christensen NJ, Warberg J, Norsk P (2002) Atrial distension, haemodilution, and acute control of renin release during water immersion in humans. Acta Physiol Scand 174:91–99PubMedGoogle Scholar
  44. 44.
    Gabrielsen A, Videbaek R, Johansen LB, Warberg J, Christensen NJ, Norsk P (1996) Immediate baroreflex-neuroendocrine interactions in humans during graded water immersion. J Gravit Physiol 3:22–23PubMedGoogle Scholar
  45. 45.
    Giannattasio C, Del BA, Cattaneo BM, Cuspidi C, Gronda E, Frigerio M et al (1993) Reflex vasopressin and renin modulation by cardiac receptors in humans. Hypertension 21:461–469PubMedGoogle Scholar
  46. 46.
    Gordon RD, Kuchel O, Liddle GW, Island DP (1967) Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J Clin Invest 46:599–605PubMedGoogle Scholar
  47. 47.
    Graffe CC, Bech JN, Pedersen EB (2012) Effect of high and low sodium intake on urinary aquaporin-2 excretion in healthy humans. Am J Physiol Ren Physiol 302:F264–F275Google Scholar
  48. 48.
    Greenleaf JE, Petersen TW, Gabrielsen A, Pump B, Bie P, Christensen NJ et al (2000) Low LBNP tolerance in men is associated with attenuated activation of the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 279:R822–R829PubMedGoogle Scholar
  49. 49.
    Gross R, Hackenberg HM, Hackenthal E, Kirchheim H (1981) Interaction between perfusion pressure and sympathetic nerves in renin release by carotid baroreflex in conscious dogs. J Physiol 313:237–250PubMedGoogle Scholar
  50. 50.
    Guillaud F, Hannaert P (2010) A computational model of the circulating renin-angiotensin system and blood pressure regulation. Acta Biotheor 58:143–170PubMedGoogle Scholar
  51. 51.
    Hackenthal E, Paul M, Ganten D, Taugner R (1990) Morphology, physiology, and molecular biology of renin secretion. Physiol Rev 70:1067–1116PubMedGoogle Scholar
  52. 52.
    Hall JE, Guyton AC, Smith MJ Jr, Coleman TG (1980) Blood pressure and renal function during chronic changes in sodium intake: role of angiotensin. Am J Physiol 239:F271–F280PubMedGoogle Scholar
  53. 53.
    Heer M, Frings-Meuthen P, Titze J, Boschmann M, Frisch S, Baecker N et al (2009) Increasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differently. Br J Nutr 101:1286–1294PubMedGoogle Scholar
  54. 54.
    Higuchi M, Asakawa T (1983) Effects of pentobarbital anesthesia on the plasma catecholamines and renin activity as reflected in the hemodynamic changes in dogs. Jpn J Pharmacol 33:209–217PubMedGoogle Scholar
  55. 55.
    Intersalt Cooperative Research Group (1988) Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 297:319–328Google Scholar
  56. 56.
    Isaksson GL, Bie P (2011) Sodium intake and renin system activity: effects of metoprolol on the log-linear relationship in conscious rats (Abstract). Acta Physiol Scand 202(suppl. 685.):93Google Scholar
  57. 57.
    Johansen LB, Bie P, Warberg J, Christensen NJ, Hammerum M, Videbaek R et al (1997) Hemodilution, central blood volume, and renal responses after an isotonic saline infusion in humans. Am J Physiol 272:R549–R556PubMedGoogle Scholar
  58. 58.
    Johansen LB, Pump B, Warberg J, Christensen NJ, Norsk P (1998) Preventing hemodilution abolishes natriuresis of water immersion in humans. Am J Physiol 275:R879–R888PubMedGoogle Scholar
  59. 59.
    Johnson MD, Malvin RL (1975) Plasma renin activity during pentobarbital anesthesia and graded hemorrhage in dogs. Am J Physiol 229:1098–1101PubMedGoogle Scholar
  60. 60.
    Kanbay M, Chen Y, Solak Y, Sanders PW (2011) Mechanisms and consequences of salt sensitivity and dietary salt intake. Curr Opin Nephrol Hypertens 20:37–43PubMedGoogle Scholar
  61. 61.
    Katholi RE, Carey RM, Ayers CR, Vaughan ED Jr, Yancey MR, Morton CL (1977) Production of sustained hypertension by chronic intrarenal norepinephrine infusion in conscious dogs. Circ Res 40:I118–I126PubMedGoogle Scholar
  62. 62.
    Kiowski W, Julius S (1978) Renin response to stimulation of cardiopulmonary mechanoreceptors in man. J Clin Invest 62:656–663PubMedGoogle Scholar
  63. 63.
    Kirchheim H, Ehmke H, Fischer S, Lowe W, Persson P (1987) Sympathetic modulation of the pressure-dependent renin release in conscious dogs. Clin Exp Hypertens 9(Suppl 1):167–180Google Scholar
  64. 64.
    Kirchheim HR, Ehmke H, Hackenthal E, Lowe W, Persson P (1987) Autoregulation of renal blood flow, glomerular filtration rate and renin release in conscious dogs. Pflügers Arch 410:441–449PubMedGoogle Scholar
  65. 65.
    Kirchheim HR, Finke R, Hackenthal E, Lowe W, Persson P (1985) Baroreflex sympathetic activation increases threshold pressure for the pressure-dependent renin release in conscious dogs. Pflügers Arch 405:127–135PubMedGoogle Scholar
  66. 66.
    Kirchheim H, Gross R (1970) Behavior of blood pressure and renal blood flow during the carotid sinus reflex in unanesthetized dogs. Comparative studies on the influence of Na-pentobarbital anesthesia and surgical preparation upon the reflex response. Pflügers Arch 315:159–172PubMedGoogle Scholar
  67. 67.
    Kjolby M, Bie P (2008) Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium. Am J Physiol Regul Integr Comp Physiol 294:R17–R25PubMedGoogle Scholar
  68. 68.
    Kleinjans JC, Smits JF, Kasbergen CM, Vervoort-Peters HT, Struyker Boudier HA (1983) Blood pressure response to chronic low-dose intrarenal noradrenaline infusion in conscious rats. Clin Sci (Lond) 65:111–116Google Scholar
  69. 69.
    Kleinjans JC, Smits JF, van Essen H, Kasbergen CM, Struyker Boudier HA (1984) Hemodynamic characterization of hypertension induced by chronic intrarenal or intravenous infusion of norepinephrine in conscious rats. Hypertension 6:689–699PubMedGoogle Scholar
  70. 70.
    Kumar R, Yong QC, Thomas CM, Baker KM (2012) Intracardiac intracellular angiotensin system in diabetes. Am J Physiol Regul Integr Comp Physiol 302:R510–R517PubMedGoogle Scholar
  71. 71.
    Kurtz A (2012) Control of renin synthesis and secretion. Am J Hypertens 25:839–847PubMedGoogle Scholar
  72. 72.
    Lang CC, Coutie WJ, Khong TK, Choy AM, Struthers AD (1991) Dietary sodium loading increases plasma brain natriuretic peptide levels in man. J Hypertens 9:779–782PubMedGoogle Scholar
  73. 73.
    Lavoie JL, Sigmund CD (2003) Minireview: overview of the renin–angiotensin system—an endocrine and paracrine system. Endocrinology 144:2179–2183PubMedGoogle Scholar
  74. 74.
    Lee ME, Thrasher TN, Ramsay DJ (1985) Mechanism of inhibition of renin secretion by increased left atrial pressure. Am J Physiol 248:R641–R644PubMedGoogle Scholar
  75. 75.
    Lohmeier TE, Tillman LJ, Carroll RG, Brown AJ, Guyton AC (1984) Malignant hypertensive crisis induced by chronic intrarenal norepinephrine infusion. Hypertension 6:I177–I182PubMedGoogle Scholar
  76. 76.
    Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K et al (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 15:545–552PubMedGoogle Scholar
  77. 77.
    Martus W, Kim D, Garvin JL, Beierwaltes WH (2005) Commercial rodent diets contain more sodium than rats need. Am J Physiol Ren Physiol 288:F428–F431Google Scholar
  78. 78.
    Molstrom S, Larsen NH, Simonsen JA, Washington R, Bie P (2009) Normotensive sodium loading in normal man: regulation of renin secretion during beta-receptor blockade. Am J Physiol Regul Integr Comp Physiol 296:R436–R445PubMedGoogle Scholar
  79. 79.
    Morganti A, Lopez-Ovejero JA, Pickering TG, Laragh JH (1979) Role of the sympathetic nervous system in mediating the renin response to head-up tilt. Their possible synergism in defending blood pressure against postural changes during sodium deprivation. Am J Cardiol 43:600–604PubMedGoogle Scholar
  80. 80.
    Myers BD, Peterson C, Molina C, Tomlanovich SJ, Newton LD, Nitkin R et al (1988) Role of cardiac atria in the human renal response to changing plasma volume. Am J Physiol 254:F562–F573PubMedGoogle Scholar
  81. 81.
    Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA (2011) Intratubular renin–angiotensin system in hypertension. Hypertension 57:355–362PubMedGoogle Scholar
  82. 82.
    Norsk P, Ellegaard P, Videbaek R, Stadeager C, Jessen F, Johansen LB et al (1993) Arterial pulse pressure and vasopressin release in humans during lower body negative pressure. Am J Physiol 264:R1024–R1030PubMedGoogle Scholar
  83. 83.
    O'Donnell CP, Scheuer DA, Keil LC, Thrasher TN (1991) Cardiac nerve blockade by infusion of procaine into the pericardial space of conscious dogs. Am J Physiol 260:R1176–R1182PubMedGoogle Scholar
  84. 84.
    Overlack A, Ruppert M, Kolloch R, Gobel B, Kraft K, Diehl J et al (1993) Divergent hemodynamic and hormonal responses to varying salt intake in normotensive subjects. Hypertension 22:331–338PubMedGoogle Scholar
  85. 85.
    Paul M, Poyan MA, Kreutz R (2006) Physiology of local renin-angiotensin systems. Physiol Rev 86:747–803PubMedGoogle Scholar
  86. 86.
    Persson P, Ehmke H, Kirchheim H, Seller H (1987) The influence of cardiopulmonary receptors on long-term blood pressure control and plasma renin activity in conscious dogs. Acta Physiol Scand 130:553–561PubMedGoogle Scholar
  87. 87.
    Persson PB, Ehmke H, Nafz B, Kirchheim HR (1990) Resetting of renal autoregulation in conscious dogs: angiotensin II and alpha1-adrenoceptors. Pflügers Arch 417:42–47PubMedGoogle Scholar
  88. 88.
    Rasmussen MS, Simonsen JA, Sandgaard NC, Hoilund-Carlsen PF, Bie P (2003) Mechanisms of acute natriuresis in normal humans on low sodium diet. J Physiol 546:591–603PubMedGoogle Scholar
  89. 89.
    Rasmussen MS, Simonsen JA, Sandgaard NC, Hoilund-Carlsen PF, Bie P (2004) Effects of oxytocin in normal man during low and high sodium diets. Acta Physiol Scand 181:247–257PubMedGoogle Scholar
  90. 90.
    Reinhart GA, Lohmeier TE, Hord CE Jr (1995) Hypertension induced by chronic renal adrenergic stimulation is angiotensin dependent. Hypertension 25:940–949PubMedGoogle Scholar
  91. 91.
    Sandgaard NC, Andersen JL, Bie P (2000) Hormonal regulation of renal sodium and water excretion during normotensive sodium loading in conscious dogs. Am J Physiol Regul Integr Comp Physiol 27:R11–R18Google Scholar
  92. 92.
    Sandgaard NC, Andersen JL, Holstein-Rathlou NH, Bie P (2005) Saline-induced natriuresis and renal blood flow in conscious dogs: effects of sodium infusion rate and concentration. Acta Physiol Scand 185:237–250PubMedGoogle Scholar
  93. 93.
    Scheuer DA, Thrasher TN, Keil LC, Ramsay DJ (1989) Mechanism of inhibition of renin response to hypotension by atrial natriuretic factor. Am J Physiol 257:R194–R203PubMedGoogle Scholar
  94. 94.
    Schnermann J (1998) Juxtaglomerular cell complex in the regulation of renal salt excretion. Am J Physiol 274:R263–R279PubMedGoogle Scholar
  95. 95.
    Schnermann J, Briggs JP (2012) Synthesis and secretion of renin in mice with induced genetic mutations. Kidney Int 81:529–538PubMedGoogle Scholar
  96. 96.
    Schweda F, Kurtz A (2012) Regulation of renin release by local and systemic factors. Rev Physiol Biochem Pharmacol 161:1–44Google Scholar
  97. 97.
    Shapiro AP, Rutan GH, Thompson ME, Nigalye RL (1990) Hypertension following orthotopic cardiac transplantation. Cardiovasc Clin 20:179–188PubMedGoogle Scholar
  98. 98.
    Shiraishi M, Schou M, Gybel M, Christensen NJ, Norsk P (2002) Comparison of acute cardiovascular responses to water immersion and head-down tilt in humans. J Appl Physiol 92:264–268PubMedGoogle Scholar
  99. 99.
    Shirataka M, Marumo F, Ando K, Sato T (1988) Response of atrial natriuretic peptide in plasma and urine to changes in dietary intake of sodium chloride in man. Jpn J Physiol 38:677–687PubMedGoogle Scholar
  100. 100.
    Skott O, Briggs JP (1987) Direct demonstration of macula densa-mediated renin secretion. Science 237:1618–1620PubMedGoogle Scholar
  101. 101.
    Smith HW (1951) The kidney: Structure and function in health and disease. Oxford University Press, New YorkGoogle Scholar
  102. 102.
    Smits JF, Kleinjans JC, Janssen BJ, Struyker-Boudier HA (1987) Characterization of hypertension induced by long-term intrarenal norepinephrine infusion in conscious rats. Clin Exp Hypertens 9(Suppl 1):197–209Google Scholar
  103. 103.
    Stocker SD, Madden CJ, Sved AF (2010) Excess dietary salt intake alters the excitability of central sympathetic networks. Physiol Behav 100:519–524PubMedGoogle Scholar
  104. 104.
    Strauss MB, Lamdin E, Smith WP, Bleifer DJ (1958) Surfeit and deficit of sodium; a kinetic concept of sodium excretion. AMA Arch Intern Med 102:527–536PubMedGoogle Scholar
  105. 105.
    Thames MD (1977) Reflex suppression of renin release by ventricular receptors with vagal afferents. Am J Physiol 233:H181–H184PubMedGoogle Scholar
  106. 106.
    Thrasher TN (1994) Baroreceptor regulation of vasopressin and renin secretion: low-pressure versus high-pressure receptors. Front Neuroendocrinol 15:157–196PubMedGoogle Scholar
  107. 107.
    Tuchelt H, Eschenhagen G, Bahr V, Schwietzer G, Thiede HM, Oelkers W (1990) Role of atrial natriuretic factor in changes in the responsiveness of aldosterone to angiotensin II secondary to sodium loading and depletion in man. Clin Sci (Lond) 79:57–65Google Scholar
  108. 108.
    Van DR, Peart WS (1974) Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat. Br J Pharmacol 50:125–129Google Scholar
  109. 109.
    Vander AJ, Geelhoed GW (1965) Inhibition of renin secretion by angiotensin. II. Proc Soc Exp Biol Med 120:399–403PubMedGoogle Scholar
  110. 110.
    Vandevijvere S, De KW, Chapelle JP, Jeanne D, Mouillet G, Huybrechts I et al (2010) Estimate of total salt intake in two regions of Belgium through analysis of sodium in 24-h urine samples. Eur J Clin Nutr 64:1260–1265PubMedGoogle Scholar
  111. 111.
    Walser M (1985) Phenomenological analysis of renal regulation of sodium and potassium balance. Kidney Int 27:837–841PubMedGoogle Scholar
  112. 112.
    Wong F, Bomzon A, Logan A, Blendis L (1995) Effects of sodium status on the venous response to noradrenaline infusion in pre-ascitic cirrhosis. Clin Sci (Lond) 88:525–531Google Scholar
  113. 113.
    Xu P, Sriramula S, Lazartigues E (2011) ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am J Physiol Regul Integr Comp Physiol 300:R804–R817PubMedGoogle Scholar
  114. 114.
    Zanchetti A, Stella A, Leonetti G, Morganti A, Terzoli L (1976) Control of renin release: a review of experimental evidence and clinical implications. Am J Cardiol 37:675–691PubMedGoogle Scholar
  115. 115.
    Zhang Y, Jose PA, Zeng C (2011) Regulation of sodium transport in the proximal tubule by endothelin. Contrib Nephrol 172:63–75PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Mads Damkjær
    • 1
  • Gustaf L. Isaksson
    • 2
  • Jane Stubbe
    • 2
  • Boye L. Jensen
    • 2
  • Kasper Assersen
    • 2
  • Peter Bie
    • 2
  1. 1.Department of PaediatricsKolding HospitalKoldingDenmark
  2. 2.Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark

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