Pflügers Archiv - European Journal of Physiology

, Volume 465, Issue 1, pp 167–175 | Cite as

Metabolic rate regulation by the renin–angiotensin system: brain vs. body

  • Justin L. Grobe
  • Kamal Rahmouni
  • Xuebo Liu
  • Curt D. Sigmund
Invited Review


Substantial evidence supports a role for the renin–angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.


Obesity Metabolism Energy homeostasis Thermogenesis 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Justin L. Grobe
    • 1
  • Kamal Rahmouni
    • 1
  • Xuebo Liu
    • 1
  • Curt D. Sigmund
    • 1
  1. 1.Department of Pharmacology, Roy J. and Lucille A. Carver College of MedicineUniversity of IowaIowa CityUSA

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