Pflügers Archiv - European Journal of Physiology

, Volume 461, Issue 2, pp 211–223 | Cite as

TRP channels and their implications in metabolic diseases

  • Zhiming Zhu
  • Zhidan Luo
  • Shuangtao Ma
  • Daoyan Liu
Invited Review


The transient receptor potential (TRP) channel superfamily is composed of 28 nonselective cation channels that are ubiquitously expressed in many cell types and have considerable functional diversity. Although changes in TRP channel expression and function have been reported in cardiovascular disease and renal disorders, the pathogenic roles of TRP channels in metabolic diseases have not been systemically reviewed. In this review, we summarised the distribution of TRP channels in several metabolic tissues and discussed their roles in mediating and regulating various physiological and pathophysiological metabolic processes and diseases including diabetes, obesity, dyslipidaemia, metabolic syndrome, atherosclerosis, metabolic bone diseases and electrolyte disturbances. This review provides new insight into the involvement of TRP channels in the pathogenesis of metabolic disorders and implicates these channels as potential therapeutic targets for the management of metabolic diseases.


Transient receptor potential channels Metabolic diseases Diabetes Obesity 



This work was supported by grants from the National Natural Science Foundation of China (Grant No. 30890042, 31000519 and 30871058) and the National Basic Research Program of China (Grant No. 2011CB503902).


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Zhiming Zhu
    • 1
  • Zhidan Luo
    • 1
  • Shuangtao Ma
    • 1
  • Daoyan Liu
    • 1
  1. 1.Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases and Chongqing Institute of Hypertension, Daping HospitalThird Military Medical UniversityChongqingChina

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