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Pflügers Archiv - European Journal of Physiology

, Volume 460, Issue 6, pp 953–964 | Cite as

Physiological carbon dioxide, bicarbonate, and pH sensing

  • Martin Tresguerres
  • Jochen Buck
  • Lonny R. Levin
Invited Review

Abstract

In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO2, HCO 3 , and H+), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO2/HCO 3 /pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO2, HCO 3 , and pH.

Keywords

Adenylyl cyclase Bicarbonate Carbon dioxide Carbonic anhydrase Channels pH Protons Sensory transduction 

Notes

Acknowledgements

We thank Dr. Carsten Wagner (University of Zurich, Switzerland) for the insightful comments on the manuscript.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Martin Tresguerres
    • 1
  • Jochen Buck
    • 1
  • Lonny R. Levin
    • 1
  1. 1.Department of Pharmacology, Weill Cornell Medical CollegeCornell UniversityNew YorkUSA

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