Invited review: activity-induced angiogenesis

  • Stuart EggintonEmail author
Cardiovascular Physiology


The dynamic biochemical and mechanical environment around blood vessels during muscle activity generates powerful stimuli for vascular remodelling. Ultimately, this must lead to a coordinated expansion of various elements of the cardiovascular system in order to support enhanced aerobic exercise. Vascular endothelial growth factor plays a central role, and understanding how this is regulated in vivo by changes in transcription and stability of mRNA, production of protein and interaction with other growth factors, is a continuing challenge. Exercise hyperaemia leads to an increase in microvascular shear stress, which stimulates endothelial release of nitric oxide, whilst proteolytic modification of the extracellular matrix is induced by mechanical deformation during cyclical contractions or muscle overload. These components of the exercise response lead to different forms of capillary growth, and subsequent expansion of the microcirculation may not have the same functional outcome. In vitro and in vivo studies have shown a complex interplay between different cytokines, receptors and mural cells in directing the necessary tissue re-organisation. The mechanisms involved in arteriogenesis are less well-understood than those of angiogenesis, but application of these data to understanding vascular remodelling in response to exercise may help resolve a range of cardiovascular dysfunction.


Angiogenesis Exercise Growth factors Remodelling Skeletal muscle Training 





numerical capillary to fibre ratio


capillary density


chronic (congestive) heart failure


endothelial cells


extracellular matrix


endothelial nitric oxide synthase


endothelial progenitor cells


fibroblast growth factor


hypoxia-inducible factor


maximal oxygen consumption


matrix metalloproteinases


nitric oxide synthase


platelet-derived growth factor




placental growth factor


receptor tyrosine kinase


transforming growth factor


tissue inhibitors of matrix metalloproteinases


vascular endothelial growth factor


VEGF receptor


vascular smooth muscle


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Angiogenesis Research Group, Centre for Cardiovascular SciencesUniversity of Birmingham Medical SchoolBirminghamUK

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