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Pflügers Archiv - European Journal of Physiology

, Volume 455, Issue 6, pp 1081–1088 | Cite as

Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients

  • Young-Joo Kim
  • Young-Oh Shin
  • Jun-Sang Bae
  • Jeong-Beom LeeEmail author
  • Joo-Hyun Ham
  • Youn-Jung Son
  • Jung-Kyu Kim
  • Chul Kim
  • Byoung-Kwon Lee
  • Jae-Keun Oh
  • Timothy Othman
  • Young-Ki Min
  • Hun-Mo Yang
Exercise, Temperature Regulation

Abstract

Recent studies showed that tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as high-sensitive C-reactive protein (hsCRP) levels are predictive factors of cardiovascular risk. However, the effect of cardiac rehabilitation (CR) intervention in coronary artery disease (CAD) patients on these factors is not known. The aim of this study was to evaluate the effects of CR and exercise on hsCRP and inflammatory cytokine levels in patients with CAD after percutaneous coronary intervention (PCI). CAD patients who underwent PCI were divided into a CR and exercise group (CRE, n = 29) or a control group (CON, n = 10). CR and exercise consisted of 6 weeks supervised exercise training and 8 weeks home-based, self-managed exercise. Compared to pre-experimental levels, TNF-α (by 20.4%; p = 0.006) and IL-6 (by 49.0%; p < 0.0001), as well as hsCRP (by 59.4%; p < 0.0001), were markedly decreased after CR and exercise in CAD patients but not in control group, except for IL-6 (by 41.6%; p = 0.001). However, there was no significant alteration of adiposity-related variables such as BMI, percent body fat, and waist circumferences, in both groups. We suggest that CR and exercise in CAD patients after PCI induce significant reduction in hsCRP and inflammatory cytokines (TNF-α and IL-6), and marked increase in exercise tolerance and capacity.

Keywords

Cardiac rehabilitation Exercise High-sensitive C-reactive protein Inflammatory cytokines Coronary artery disease Percutaneous coronary intervention Tumor necrosis factor- α Interleukin-6 

Notes

Acknowledgments

This work was supported by the Regional Innovation Center (RIC) of Soonchunhyang University. Young-Joo Kim, Young-Oh Shin, and Jun-Sang Bae contributed equally to this work.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Young-Joo Kim
    • 4
  • Young-Oh Shin
    • 1
  • Jun-Sang Bae
    • 1
  • Jeong-Beom Lee
    • 1
    Email author
  • Joo-Hyun Ham
    • 1
  • Youn-Jung Son
    • 2
  • Jung-Kyu Kim
    • 3
  • Chul Kim
    • 4
  • Byoung-Kwon Lee
    • 5
  • Jae-Keun Oh
    • 6
  • Timothy Othman
    • 7
  • Young-Ki Min
    • 1
  • Hun-Mo Yang
    • 1
  1. 1.Department of Physiology, College of MedicineSoonchunhyang UniversityCheonanRepublic of Korea
  2. 2.Department of Nursing, College of MedicineSoonchunhyang UniversityCheonanRepublic of Korea
  3. 3.Department of Leisure SportsKangwon National UniversitySamcheokRepublic of Korea
  4. 4.Department of Rehabilitation Medicine, College of MedicineInje UniversitySeoulRepublic of Korea
  5. 5.Department of Internal Medicine, College of MedicineInje UniversitySeoulRepublic of Korea
  6. 6.Department of Sports MedicineKorea National Sport UniversitySeoulRepublic of Korea
  7. 7.Huntingdon Life SciencesPrinceton Research CenterSomersetUSA

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