Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

Invited Review


Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.


PIP2 PIP5K Actin cytoskeleton Arf6 Endocytosis Phagocytosis 


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© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of PhysiologyUniversity of Texas Southwestern Medical CenterDallasUSA

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