Pflügers Archiv

, Volume 453, Issue 1, pp 11–22

What’s new in ion transports in the cochlea?

  • Vincent Couloigner
  • Olivier Sterkers
  • Evelyne Ferrary
Invited Review

Abstract

Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K+ through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K+ by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K+ recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.

Keywords

Inner ear fluids Potassium Sodium Acid-base Endolymph Connexin Hearing Deafness 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Vincent Couloigner
    • 1
    • 2
  • Olivier Sterkers
    • 1
    • 3
  • Evelyne Ferrary
    • 1
    • 3
  1. 1.Inserm EMI U-0112Faculté Xavier BichatParisFrance
  2. 2.Pediatric ENT DepartmentHôpital Necker–Enfants MaladesParisFrance
  3. 3.ENT DepartmentHôpital BeaujonParisFrance

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