Pflügers Archiv

, Volume 452, Issue 5, pp 486–500

Molecular properties of P2X receptors

  • Jonathan A. Roberts
  • Catherine Vial
  • Helen R. Digby
  • Kelvin C. Agboh
  • Hairuo Wen
  • Amelia Atterbury-Thomas
  • Richard J. Evans
Invited Review

DOI: 10.1007/s00424-006-0073-6

Cite this article as:
Roberts, J.A., Vial, C., Digby, H.R. et al. Pflugers Arch - Eur J Physiol (2006) 452: 486. doi:10.1007/s00424-006-0073-6

Abstract

P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X1-7) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range of phenotypes. This review aims to give an account of recent work on the molecular basis of the properties of P2X receptors. In particular, to consider emerging information on the assembly of P2X receptor subunits, channel regulation and desensitisation, targeting, the molecular basis of drug action and the functional contribution of P2X receptors to physiological processes.

Keywords

ATP P2X receptors Regulation Transgenic mice Mutagenesis 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jonathan A. Roberts
    • 1
  • Catherine Vial
    • 1
  • Helen R. Digby
    • 1
  • Kelvin C. Agboh
    • 1
  • Hairuo Wen
    • 1
  • Amelia Atterbury-Thomas
    • 1
  • Richard J. Evans
    • 1
  1. 1.Department of Cell Physiology & Pharmacology,Medical Sciences BuildingUniversity of LeicesterLeicesterUK

Personalised recommendations