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Pflügers Archiv

, Volume 452, Issue 5, pp 538–551 | Cite as

Functions of neuronal P2Y receptors

  • Simon Hussl
  • Stefan BoehmEmail author
Invited Review

Abstract

Within the last 15 years, at least eight different G protein-coupled nucleotide receptors, i.e., P2Y receptors, have been characterized by molecular means. While ionotropic P2X receptors are mainly involved in fast synaptic neurotransmission, P2Y receptors rather mediate slower neuromodulatory effects. This P2Y receptor-dependent neuromodulation relies on changes in synaptic transmission via either pre- or postsynaptic sites of action. At both sites, the regulation of voltage-gated or transmitter-gated ion channels via G protein-linked signaling cascades has been identified as the predominant underlying mechanisms. In addition, neuronal P2Y receptors have been found to be involved in neurotoxic and neurotrophic effects of extracellular adenosine 5-triphosphate. This review provides an overview of the most prominent actions mediated by neuronal P2Y receptors and describes the signaling cascades involved.

Keywords

G proteins P2Y receptor Voltage-gated Ca2+ channel Voltage-gated K+ channel Synaptic transmission 

Notes

Acknowledgements

Work in the authors’ laboratory is supported by grants from the Austrian Science Fund, FWF (P15797 and P17611), and from the Virologiefonds of the Medical University of Vienna.

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© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Center of Biomolecular Medicine and Pharmacology, Institute of PharmacologyMedical University of ViennaViennaAustria

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