Pflügers Archiv

, 452:260 | Cite as

Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythm

  • P. Oliver
  • J. Ribot
  • A. M. Rodríguez
  • J. Sánchez
  • C. Picó
  • A. Palou
Adaptation, Biorhythms


Resistin and adiponectin are adipokines with postulated opposite functions. Resistin has been related with insulin resistance in obesity, while adiponectin could be associated to higher insulin sensitivity. We have determined whether the production of these two adipokines during the day is related to the feeding rhythm in rats. Resistin mRNA levels in adipose tissue correlated positively with the gastric contents and serum insulin concentration, showing higher levels during the dark phase (period of the highest food intake), especially in the mesenteric depot, while levels decreased during the light phase. The diurnal pattern of resistin expression was not directly reflected in the circulating levels, but it showed a 6-h delay and correlated negatively with the gastric contents and serum insulin. Adiponectin expression followed an opposite pattern, not apparently related to feeding or insulin release, and not translated into changes in circulating levels. Moreover, considering that insulin stimulates resistin expression and that circulating resistin follows a contrary circadian pattern in comparison to insulin, resistin, apart from its role in the increased insulin resistance associated to obesity, could also act as a putative modulator of insulin in the daily feeding/fasting rhythm through a negative feedback regulation of its action.


Resistin Adiponectin Insulin action Circadian rhythm Feeding status 



This work was supported by the Spanish Government (grants G03/028, BFI2003-04439 and AGL 2004-07496/ALI). Our Laboratory is a member of the European Research Network of Excellence NuGO [The European Nutrigenomics Organization, EU Contract: FOOD-CT-2004-506360 NUGO (NOE)]. J.S. is a recipient of a fellowship from the Spanish Government.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • P. Oliver
    • 1
  • J. Ribot
    • 1
  • A. M. Rodríguez
    • 1
  • J. Sánchez
    • 1
  • C. Picó
    • 1
  • A. Palou
    • 1
  1. 1.Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health SciencesUniversity of the Balearic IslandsPalma de MallorcaSpain

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