Pflügers Archiv

, Volume 449, Issue 1, pp 1–15 | Cite as

Human pulmonary vascular responses to hypoxia and hypercapnia

  • K. L. DorringtonEmail author
  • N. P. Talbot
Invited Review


The ability of alveolar gas composition to influence pulmonary vascular tone has been appreciated for over 50 years. In particular, it has been proposed that both O2 and CO2 could play a role in the matching of perfusion to ventilation within the lung, improving the overall efficiency of gas exchange. A wide variety of experimental approaches has been used to investigate pulmonary vascular effects of the respiratory gases in a range of mammalian species. In this article, we review experiments performed in healthy humans, identify particular difficulties in the interpretation of such experiments, and discuss possible approaches to future study.


Hypoxic pulmonary vasoconstriction Hypoxia Hypercapnia Human Ventilation-perfusion matching 



The authors would like to thank Professor Nigel West for helpful comments on this manuscript. This work was funded by the Dunhill Medical Trust.


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Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.University Laboratory of PhysiologyOxfordUnited Kingdom

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