Pflügers Archiv

, Volume 447, Issue 5, pp 813–815 | Cite as

The sodium/glucose cotransport family SLC5

Erratum

Pflugers Arch - Eur J Physiol (2003) DOI 10.1007/s00424-003-1063-6

Figure 1 and Table 1 have been revised to reflect the recently approved HUGO gene names for newer members of the SLC5 family, namely those for AIT (SLC5A8) and SGLTs 4-6 (SLC5A9-11). In addition, a reference has been added documenting the function of SGLT3 (SLC5A4) as a glucose sensor.
Fig. 1

Unrooted phylogenetic tree of the 11 human members of the SLC5 family of cotransporters and two other vertebrate members of known function. The alignment program CLUSTAL W (http://www.ebi.ac.uk/clustalw/) and the phylogenetic display program TreeViewPPC (http://taxonomy.zoology.gla.ac.uk/rod/treeview.html) were used to generate the tree. Members for which transport functions have been demonstrated experimentally are shown in red. Members shown in black have yet to have their function determined. In a pairwise basic local alignment search tool (BLAST) analysis the amino acid identities relative to SGLT1 (SLC5A1) were 59% SGLT2, 70% SGLT3, 56% SGLT4, 57% SGLT5, 50% SGLT6, 55% SMIT, 24% SMVT, 24% CHT, 21% AIT, and 21% NIS (SGLT Na+/glucose transporter, SMIT Na+/myo-inositol transporter, SMVT Na+/multivitamin transporter, CHT choline transporter, AIT apical iodide transporter, NIS Na+/iodide transporter)

Table 1

The SLC5 sodium glucose cotransporter family (OMIM Online Mendelian Inheritance in Man database, TMHtransmembrane helix, aa amino acids)

Human gene name

Protein name

Aliases

Predominant substrates

Transport type/coupling ion*

Tissues distribution and cellular/subcellular expressionT

Link to disease

Human gene locus

Sequence accession ID

Splice variants and their specific featuresS

SLC5A1

SGLT1

None

Glucose and galactose (urea and water)

C/Na+ (H+) F/Na+ (H+). Channel: urea and water

Small intestine>>>>trachea, kidney and heart; plasma membranes

Glucose galactose malabsorptionG OMIM 182380

22q13.1

NM_000343

SLC5A2

SGLT2

None

Glucose

C/Na+

Kidney cortex

Familial renal glycosuriaG OMIM 182381

16p12-p11

NM_003041

SLC5A3

SMIT

None

myo-inositol (glucose)

C/Na+

Brain, heart, kidney and lung; plasma membranes

Down’s syndrome? OMIM 600444

21q22.12

NM_006933

Splicing within, and distal to exon 2 leads to 3 transcripts (SMIT1, SMIT2, SMIT3). SMIT2 and -3 lack the 14th TMH

SLC5A4

SGLT3

SAAT1

Na+ (H+)

Glucose sensorU

Small intestine (cholinergic neurons), skeletal muscle, kidney, uterus and testis; plasma membranes

22q12.2-q12.3

NM_14227

SLC5A5

NIS

I(ClO4, SCN, NO3, Br)

C/Na+ Uniporter Na+ Channel Urea water

Thyroid, breast, colon and ovary; plasma membranes

Thyroid hormonogenesisG OMIM 601843

19p13.2-p12

NM_ 000453

SLC5A6

SMVT

Biotin, lipoate and pantothenate

C/Na+

Brain, heart, kidney, lung and placenta; plasma membranes

2p23

NM _021095

SLC5A7

CHT

CHT1

Choline

C/Na+/Cl

Spinal cord and medulla (intracellular vesicles)

2q12

NM _021815

SLC5A8

AIT

Iodide

?

Thyroid, apical plasma membrane

12q23.1

NM_145913

SLC5A9**

SGLT4

 

Small intestine, kidney; liver, lung and brain

1p32

HCT1951464

Alternative splice in exon 14 yields either 38 or 53 aa between TMHs 13–14

SLC5A10

SLGT5

Rabbit RK-D

Kidney

17p11.2

XM_064487

First 16 aas of exon 10 may be spliced out. An additional 37 aa exon may bge spliced in between exons 11 and 12

SLC5A11

SGLT6

KST1 Rabbit ST1 Rabbit SMIT2

Rabbit ortholog: myo-inositol, chiro-inositol, glucose and xylose. Xenopus laevis ortholog:myo-inositol and glucose

C/Na+

Small intestine, brain, kidney, liver, heart, and lung

16p12.1

NM_052944

Splicing eliminates exon 6 and TMH 4

*C cotransporter; F uniporter. Function based on results obtained with heterologous expression systems

**Provisional SGLT4 exons identified by mining the Celera databases

TTissue distribution of SGLT1–6 was determined by RNAase protection assays using gene specific probes (Bing M, Turk E, Martin MG, Wright EM, in preparation). Also includes data from the original cloning papers and GeneCard (EST, and/or DNA array)

GGene defect

SPotential alternative splice sites identified by Roll et al. (2002), Porcellati et al. (1999) and Turk (unpublished)

Original references may be obtained through the Accession numbers and/or the text

UDiez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (2003) A glucose sensor hiding in a family of transporters. Proc Nat Acad Sci (USA) 100:11753–11758

Note: single nucleotide polymorphisms (SNPs) and variants in the NCBI SNP database are not included

Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.Department of PhysiologyDavid Geffen School of Medicine at UCLALos AngelesUSA

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