Pflügers Archiv

, Volume 447, Issue 3, pp 267–271

Pflügers Archiv and the advent of modern electrophysiology

From the first action potential to patch clamp
Milestones in Physiology


This short review recollects the many essential milestones in electrophysiology that were published in Pflügers Archiv. These involve the first measurement of an action potential by J. Bernstein, the requirement of Na+ for the generation of excitation, the prediction of a lipoid membrane surrounding cells by E. Overton, the physical explanation of the resting membrane potential by J. Bernstein, the first detailed description of the conductance properties of excitable tissues by L. Hermann, and more recently the publication of the patch-clamp method by E. Neher and B. Sakmann.


Action potential Electrophysiology History Patch clamp Resting potential 

Copyright information

© Springer-Verlag  2003

Authors and Affiliations

  1. 1.Laboratorium voor FysiologieKU LeuvenLeuvenBelgium

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