Pflügers Archiv

, Volume 447, Issue 5, pp 566–570

The sodium bile salt cotransport family SLC10

The ABC of Solute Carriers Guest Editor: Matthias A. Hediger

DOI: 10.1007/s00424-003-1130-z

Cite this article as:
Hagenbuch, B. & Dawson, P. Pflugers Arch - Eur J Physiol (2004) 447: 566. doi:10.1007/s00424-003-1130-z

Abstract

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

Keywords

Bile salt Enterohepatic circulation NTCP ASBT Liver Intestine Proximal tubule Cotransport 

Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.Division of Clinical Pharmacology and Toxicology, Department of MedicineUniversity HospitalZurichSwitzerland
  2. 2.Wake Forest University School of MedicineWinston-SalemUSA

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