Pflügers Archiv

, Volume 447, Issue 5, pp 784–795 | Cite as

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

  • Bryan MackenzieEmail author
  • Jeffrey D. EricksonEmail author
The ABC of Solute carriers Guest Editor: Matthias A. Hediger


The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive. The System N subtypes SNAT3 and SNAT5 also countertransport H+, which may be key to their operation in reverse, and have narrower substrate profiles than do the System A subtypes. Glutamine emerges as a favored substrate throughout the family, except for SNAT4. The SLC38 transporters undoubtedly play many physiological roles including the transfer of glutamine from astrocyte to neuron in the CNS, ammonia detoxification and gluconeogenesis in the liver, and the renal response to acidosis. Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia.


Glutamine transport Amino acid transport Glutamate-glutamine cycle Adaptive regulation SNAT6 Gluconeogenesis Ammonia detoxification 


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Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.Membrane Biology Program and Renal DivisionBrigham and Women's Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Neuroscience Center and Department of PharmacologyLouisiana State University Health Sciences CenterNew OrleansUSA

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