A current review of fatty acid transport proteins (SLC27)
Long-chain fatty acids (LCFAs) are not only important metabolites but contribute to many cellular functions including activation of protein kinase C (PKC) isoforms and nuclear transcription factors such as peroxisome proliferator-activated receptors (PPAPs). To assert their diverse effects LCFAs have first to traverse the plasma membrane, a process that can occur either through diffusion or be mediated by proteins. Considerable evidence has accumulated to show that in addition to a diffusional component, the intestine, heart, adipose tissue, and the liver express a saturable and specific LCFA transport system. Identifying the postulated fatty acid transporters is of considerable importance, since both increased and decreased fatty acid uptake have been implicated in diseases such as type-2 diabetes and acute liver failure. Fatty acid transport proteins (FATPs/solute carrier family 27) are integral transmembrane proteins that enhance the uptake of long-chain and very long chain fatty acids into cells. In humans FATPs comprise a family of six highly homologous proteins, hsFATP1–6, which are found in all fatty acid-utilizing tissues of the body. This review will focus on a brief discussion of FATP expression patterns, regulation, structure, and mechanism of transport.
KeywordsFatty acid transport proteins FATP Solute carrier family 27 Fatty acid uptake Metabolism
I thank Dr. Allen D. Cooper and Mrs. Kathe O'Hearn for critical reading of this manuscript and valuable suggestions. This work was supported by a training and feasibility grant from the Digestive Disease Center, Stanford University and by a Beginning Grant-in-Aid from the American Heart Association (0265311Y).
- 4.Binnert C, Koistinen HA, Martin G, Andreelli F, Beetling P, Koivisto VA, Laville M, Auwerx J, Vidal H (2000) Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans. Am J Physiol 279:E1072–E1079Google Scholar
- 15.Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Lodish HF, Stahl A (2003) Characterization of a heart-specific fatty acid transport protein J Biol Chem (In press)Google Scholar
- 16.Gore J, Hoinard C (1993) Linolenic acid transport in hamster intestinal cells is carrier-mediated. J Nutr 123:66–73Google Scholar
- 22.Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8:731–737PubMedGoogle Scholar