Pflügers Archiv

, Volume 447, Issue 5, pp 780–783

The human sugar-phosphate/phosphate exchanger family SLC37

The ABC of Solute Carriers Guest Editor: Matthias A. Hediger


The SLC37 family of four predicted proteins is an almost unexplored group of transmembrane sugar transporters. Of the four proteins/genes assigned to date to this family, only one is well known, the SLC37A4 gene (also known as the glucose-6-phosphate transporter 1, G6PT1) mutated in the glycogen storage disease non-1A type. Data on SLC3A1 gene expression are available for humans, while data on SLC37A2 are available for mice. The last SLC37 family member, SLC37A3, is only a putative gene/protein identified by in silico analyses. The four genes are not clustered in a single chromosome as regions and the identity of their predicted polypeptides is between 60 and 20%. Here we propose a new nomenclature for the SLC37 proteins (SPX: sugar-phosphate exchangers) numbered according to the gene numbering.


SLC37 Sugar-phosphate Channel exchanger Gene family Transmembrane proteins Transporter proteins Gene Protein 

Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.University of Padova, Dept. of Medical and Surgical SciencesPadovaItaly
  2. 2.University of Geneva Medical SchoolGenevaSwitzerland

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