Pflügers Archiv

, Volume 447, Issue 5, pp 677–682 | Cite as

Sodium-dependent ascorbic acid transporter family SLC23

  • Hitomi Takanaga
  • Bryan Mackenzie
  • Matthias A. Hediger
The ABC of Solute Carriers Guest Editor: Matthias A. Hediger

Abstract

l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na+-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.

Keywords

Antioxidation Ascorbic acid transport Dehydroascorbic acid Neuron Oxidative stress Scurvy 

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Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  • Hitomi Takanaga
    • 1
  • Bryan Mackenzie
    • 1
  • Matthias A. Hediger
    • 1
  1. 1.Membrane Biology Program and Renal DivisionBrigham & Women's Hospital and Harvard Medical SchoolBostonUSA

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