Pflügers Archiv

, Volume 446, Issue 4, pp 401–409 | Cite as

(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6

  • Tom Nijenhuis
  • Joost G. J. Hoenderop
  • Bernd Nilius
  • René J. M. BindelsEmail author
Invited Review


The epithelial Ca2+ channels TRPV5 and TRPV6 constitute the apical Ca2+ entry mechanism in active Ca2+ (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca2+ channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca2+ channels.


Calcium transport ECaC1 ECaC2 Estrogen Hypercalciuria  Vitamin D 



This work was supported in part by grants from the Dutch Kidney Foundation (C10.1881), the Dutch Organization of Scientific research (Zon-Mw 016.006.001, Zon-Mw 902.18.298, NWO-ALW 805.09.042 and NWO-ALW 810.38.004), the Belgian Federal Government, the Flemish Government and the Onderzoeksraad KU Leuven (GOA 99/07, F.W.O. G.0237.95, F.W.O. G.0214.99, F.W.O. G. 0136.00, F.W.O. 0172.03) and a grant from the "Alphonse and Jean Forton–Koning Boudewijn Stichting" (R7115 B0).


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Copyright information

© Springer-Verlag  2003

Authors and Affiliations

  • Tom Nijenhuis
    • 2
  • Joost G. J. Hoenderop
    • 2
  • Bernd Nilius
    • 3
  • René J. M. Bindels
    • 1
    • 2
    Email author
  1. 1.M850 Room 07.048Centrale Ontvangst GoederenGA NijmegenThe Netherlands
  2. 2.Department of Cell Physiology, Nijmegen Center for Molecular Life SciencesUniversity Medical Center NijmegenHB NijmegenThe Netherlands
  3. 3.Department of Physiology, Campus GasthuisbergKU LeuvenBelgium

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