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Langenbeck's Archives of Surgery

, Volume 403, Issue 8, pp 977–984 | Cite as

Supraclavicular and celiac metastases in squamous cell carcinoma of the middle thoracic esophagus

  • Akihiko Okamura
  • Masayuki WatanabeEmail author
  • Ryotaro Kozuki
  • Tasuku Toihata
  • Masami Yuda
  • Yu Imamura
  • Shinji Mine
ORIGINAL ARTICLE
  • 59 Downloads

Abstract

Purpose

Squamous cell carcinoma of the middle thoracic esophagus (SCC-ME) often metastasizes to the neck, mediastinum, and abdomen. This study aims to assess the prognostic impact of supraclavicular (SC) and celiac (CE) lymph node (LN) metastases in patients with SCC-ME.

Methods

We examined 210 patients who underwent curative esophagectomy with three-field LN dissection for SCC-ME. The clinicopathological features and survival outcomes of patients with and without SC and/or CE metastases were compared to assess the prognostic significance of SC and/or CE metastases.

Results

We observed metastases to SC and CE in 25 (11.9%) and 20 (9.5%) patients, respectively. Seven patients (3.3%) had both SC and CE metastases. Although the survival of patients with SC and/or CE metastases was worse compared with those without, that of patients with SC metastases but without CE metastases was comparable with that of patients with CE metastases but without SC metastases; the 5 year overall survival rates were 35.6% and 46.2%, respectively. However, survival of patients with both SC and CE metastases was the worst among all groups, and all patients with both SC and CE metastases experienced disease recurrence.

Conclusions

The prognosis of patients with both SC and CE metastases was extremely poor. In contrast, patients with metastasis to either one of these sites could be candidates for surgery as the main modality in a multidisciplinary strategy.

Keywords

Esophageal squamous cell carcinoma Lymph node metastasis Supraclavicular metastasis Celiac metastasis Prognosis 

Notes

Authors’ contributions

Study conception and design: all authors. Acquisition of data: all authors. Analysis and interpretation of data: Okamura, Watanabe, and Mine. Drafting of manuscript: Okamura, Watanabe, and Mine. Critical revision of manuscript: all authors.

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This article does not contain any studies with animals performed by any of the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Akihiko Okamura
    • 1
  • Masayuki Watanabe
    • 1
  • Ryotaro Kozuki
    • 1
  • Tasuku Toihata
    • 1
  • Masami Yuda
    • 1
  • Yu Imamura
    • 1
  • Shinji Mine
    • 1
  1. 1.Department of Gastroenterological Surgery, Gastroenterology CenterThe Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan

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