High admission C-reactive protein level and longer in-hospital delay to surgery are associated with increased risk of complicated appendicitis
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Debate on the effect of in-hospital delay on the risk of perforation in appendicitis persists, and the results from previous studies are controversial. The aims of this study were to present the effect of in-hospital delay on the risk of perforation in appendicitis and to assess the utility of C-reactive protein (CRP) measurement in detecting the patients with complicated appendicitis.
Prospectively collected data of 389 adult patients who underwent surgery for acute appendicitis were analyzed in order to find the most accurate method for recognizing the pre-hospital perforations. The effect of in-hospital delay on the further risk of perforation in patients with not yet perforated acute appendicitis was then analyzed.
Out of 389 patients with appendicitis, 91 patients (23.4 %) had complicated appendicitis, 23 with abscess, and 68 with free perforation. Admission CRP level of 99 mg/l or higher was 90.3 % specific for complicated appendicitis. In patients with admission CRP less than 99 mg/l, the incidence of perforation doubled from 9.5 to 18.9 % when the in-hospital delay increased from less than 6 h to more than 12 h.
Complicated appendicitis can be identified with a high CRP level on admission. Delaying surgery can increase the risk of perforation.
KeywordsAppendicitis, acute Appendicitis, perforated Abdomen, acute C-reactive protein
Conflicts of interest
Study conception and design: Leppäniemi and Mentula
Acquisition of data: Sammalkorpi
Analysis and interpretation of data: Mentula and Sammalkorpi
Drafting of manuscript: Sammalkorpi and Mentula
Critical revision of manuscript: Leppäniemi and Mentula
- 4.Temple CL, Huchcroft SA, Temple WJ (1995) The natural history of appendicitis in adults. A Prospect Stud Annals Surg 221(3):278–281Google Scholar
- 12.United Kingdom National Surgical Research, C, Bhangu A (2014) Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg 259(5):894–903Google Scholar
- 13.Farooqui W, Pommergaard HC, Burcharth J, Eriksen JR (2014) The diagnostic value of a panel ofserological markers in acute appendicitis. Scand J Surg 0:1-7Google Scholar
- 19.Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–13Google Scholar